Aberrant Glycosylation of Anchor-Optimized MUC1 Peptides Can Enhance Antigen Binding Affinity and Reverse Tolerance to Cytotoxic T Lymphocytes

Aberrant Glycosylation of Anchor-Optimized MUC1 Peptides Can Enhance Antigen Binding Affinity and Reverse Tolerance to Cytotoxic T Lymphocytes

LB Pathangey, V Lakshminarayanan, VJ Suman… - Biomolecules, 2016 - mdpi.com

... Tn-modifications were introduced at the fifth amino acid position of the peptide by using
Fmoc-Thr(GalNAc(Ac 3 )-α-D)-OH (Bachem Bioscience, King of Prussia, PA, USA). Peptides
were purified on the Beckman System Gold HPLC using a Jupiter Proteo C12 column ...

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