Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties
M Demeule, N Beaudet, A Régina… - The Journal of …, 2014 - Am Soc Clin Investig
... BBB penetration of larger molecules, such as therapeutic peptides or proteins, represents the
next challenge, for which we established 2 requirements. First, CNS activity of the peptide should
be readily measurable to allow for clear demonstration of functional activity. ...
next challenge, for which we established 2 requirements. First, CNS activity of the peptide should
be readily measurable to allow for clear demonstration of functional activity. ...

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