Different susceptibility of B-type natriuretic peptide (BNP) and BNP precursor (proBNP) to cleavage by neprilysin: the N-terminal part does matter

Different susceptibility of B-type natriuretic peptide (BNP) and BNP precursor (proBNP) to cleavage by neprilysin: the N-terminal part does matter

AG Semenov, AG Katrukha - Clinical chemistry, 2016 - clinchem.aaccjnls.org

... to be responsible for the degradation of natriuretic peptides. A recent heart failure (HF) drug,
LCZ696 (Entresto TM ), that combines a neprilysin inhibitor and an angiotensin II receptor inhibitor
was suggested to augment circulating B-type natriuretic peptide (BNP) concentrations ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com