Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy- …

Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy- …

SL Wagner, C Zhang, S Cheng, P Nguyen, X Zhang… - Biochemistry, 2014 - ACS Publications

... It cleaves β-secretase-cleaved APP-CTFs to produce each Aβ peptide variant. Once released
from the membrane, longer Aβ peptides (eg, Aβ42) oligomerize, ultimately forming insoluble
deposits.(13) One therapeutic approach to AD was focused on lowering the total level of ...

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