H-RN, a novel antiangiogenic peptide derived from hepatocyte growth factor inhibits inflammation in vitro and in vivo through PI3K/AKT/IKK/NF-κB signal pathway

H-RN, a novel antiangiogenic peptide derived from hepatocyte growth factor inhibits inflammation in vitro and in vivo through PI3K/AKT/IKK/NF-κB signal pathway

L Wang, Y Xu, Q Yu, Q Sun, Y Xu, Q Gu, X Xu - Biochemical pharmacology, 2014 - Elsevier

Abstract H-RN, a novel antiangiogenic peptide derived from the kringle 1 domain of
hepatocyte growth factor (HGF), consists of the sequence RNPRGEEGGPW (molecular
weight: 1254.34 Da). Emerging evidence indicates that HGF and the kringle domain exhibit

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