[HTML] Monosubstituted alkenyl amino acids for peptide “stapling”
DJ Yeo, SL Warriner, AJ Wilson - Chemical Communications, 2013 - pubs.rsc.org
The elaboration of approaches to modulate protein–protein interactions (PPIs) is a highly sought
after goal in contemporary chemical biology and drug discovery, 1,2 with significant effort focused
on α-helix mediated PPIs. 3 In this regard, constrained peptides 4–9 have emerged as promising
after goal in contemporary chemical biology and drug discovery, 1,2 with significant effort focused
on α-helix mediated PPIs. 3 In this regard, constrained peptides 4–9 have emerged as promising
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