2018年5月15日星期二

Development of a solid‐phase traceless‐Ugi multicomponent reaction for backbone anchoring and cyclic peptide synthesis

Development of a solid‐phase traceless‐Ugi multicomponent reaction for backbone anchoring and cyclic peptide synthesis

S Jobin, C Beaumont, E Biron - Peptide Science, 2018 - Wiley Online Library
A new one‐pot methodology to anchor peptides by their backbone to a solid support using
an isocyanide‐based multicomponent reaction is described. The approach uses a
microwave‐assisted Ugi four‐component reaction to simultaneously condense and bind an …

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