Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction
RJ Steel, MA O'Connell, M Searcey - Bioorganic & medicinal chemistry …, 2018 - Elsevier
Abstract The Nrf2/Keap1 interaction is a target in the development of new therapeutic
agents, where inhibition of the interaction activates Nrf2 and leads to the generation of
downstream anti-inflammatory effects. Peptides that mimic the β-turn in the Keap1 active site …
agents, where inhibition of the interaction activates Nrf2 and leads to the generation of
downstream anti-inflammatory effects. Peptides that mimic the β-turn in the Keap1 active site …
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