2018年5月9日星期三

Synthetic Molecular Evolution of Hybrid Cell Penetrating Peptides that Efficiently Deliver Peptide and Peptide Nucleic Acid Cargoes to Cells

Synthetic Molecular Evolution of Hybrid Cell Penetrating Peptides that Efficiently Deliver Peptide and Peptide Nucleic Acid Cargoes to Cells

W Kauffman, W Wimley - Biophysical Journal, 2018 - cell.com
Peptides and peptide nucleic acids (PNAs) have long been recognized as promising tools
and potential therapeutics. Yet the cell membrane remains a significant barrier to their
intracellular targets. Conjugation to cell penetrating peptides (CPPs) like pTat48-60 (tat) and …


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