2018年5月13日星期日

The interaction between androgen receptor and semenogelin I: a synthetic LxxLL peptide antagonist inhibits the growth of prostate cancer cells

The interaction between androgen receptor and semenogelin I: a synthetic LxxLL peptide antagonist inhibits the growth of prostate cancer cells

P Li, J Chen, E Kashiwagi, T Mizushima, B Han… - British journal of …, 2018 - nature.com
Background: We previously demonstrated that a seminal plasma protein, semenogelin I
(SgI), functioned as an androgen receptor (AR) coactivator. Meanwhile, several short
sequence motifs in AR coregulators, such as LxxLL (L= leucine), have been shown to …

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