2017年7月3日星期一

Bicyclic peptide inhibitor reveals large contact interface with a protease target

Bicyclic peptide inhibitor reveals large contact interface with a protease target

A Angelini, L Cendron, S Chen, J Touati… - ACS chemical …, 2012 - ACS Publications
... We isolated the bicyclic peptide inhibitors from a combinatorial repertoire of peptides (library
1: 4.0 × 10 9 different peptides; Figure 1A) that had been cyclized by the trifunctional
tris(bromomethyl)benzene (TBMB)(10) on the surface of filamentous bacteriophage,(11) panning ...



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