Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases

Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases

V Baeriswyl, H Rapley, L Pollaro, C Stace… - …, 2012 - Wiley Online Library

... Peptides were eluted under reducing conditions and partially purified by precipitation. ... in
mammalian cells as an inactive precursor having a short peptide connected to ... values, the following
7-amino-4-methylcoumarin (AMC)-derived fluorogenic substrates (Bachem) were used ...

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