Bicyclization and tethering to albumin yields long-acting peptide antagonists

Bicyclization and tethering to albumin yields long-acting peptide antagonists

A Angelini, J Morales-Sanfrutos… - Journal of medicinal …, 2012 - ACS Publications

... Examples are the peptide hormones oxytocin, somatostatin, and atrial natriuretic peptide, which
have longer half ... For example, a library rich in multicyclic peptides (termed Melusine) was
generated by ... of more than 1200 animal venoms and is provided by Atheris/Bachem.(13). ...

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