Durable pharmacological responses from the peptide ShK-186, a specific Kv1. 3 channel inhibitor that suppresses T cell mediators of autoimmune disease

Durable pharmacological responses from the peptide ShK-186, a specific Kv1. 3 channel inhibitor that suppresses T cell mediators of autoimmune disease

EJ Tarcha, V Chi, EJ Muñoz-Elías, D Bailey… - … of Pharmacology and …, 2012 - ASPET

... fold to a major thermodynamically favored isomer, which is the biologically active form of the
peptides. ... Fifty microliters of an internal standard [2 μg/ml ShK (parent peptide; accession number
P29187)] in 90:10 H 2 O/ACN (v/v) (Bachem, Bubendorf, Switzerland) were ...

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