Peptide Synthesis: … hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides

2017年7月3日星期一

… hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides

H Rueeger, R Lueoend, O Rogel… - Journal of medicinal …, 2012 - ACS Publications

... 1) Pathological hallmarks of AD are neuritic plaques containing aggregated amyloid-β (Aβ)
peptides as the core component and neurofibrillar tangles of aggregated τ protein. Considerable
evidence has accumulated indicating a central role of the Aβ peptide and more ...

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Peptide Synthesis

2017年7月3日星期一

… hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides

… hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides

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