Native chemical ligation of thioamide-containing peptides: development and application to the synthesis of labeled α-synuclein for misfolding studies

Native chemical ligation of thioamide-containing peptides: development and application to the synthesis of labeled α-synuclein for misfolding studies

S Batjargal, YJ Wang, JM Goldberg… - Journal of the …, 2012 - ACS Publications

... Mechanism and (Bottom) Potential Thioamide Side Reactions. We began by synthesizing
thioamide-containing C-terminal thioesters or N-terminal Cys peptides and testing their
compatibility with NCL. Since the HF cleavage step of Boc-based peptide synthesis degrades ...

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