Obesity is associated with poor response to clopidogrel and an increased susceptibility to protease activated receptor-1 mediated platelet activation

Obesity is associated with poor response to clopidogrel and an increased susceptibility to protease activated receptor-1 mediated platelet activation

T Gremmel, S Steiner, D Seidinger… - Translational …, 2013 - Elsevier

... was diluted in phosphate buffered saline to obtain 20 x 10 3 platelets and incubated after in vitro
exposure to suboptimal concentrations of ADP (1μM; Dynabyte, Munich, Germany), or thrombin
receptor activating peptide-6 (TRAP-6, 5.7 μM; Bachem, Bubendorf, Switzerland) for ...

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