Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease

Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease

C Nitsche, MAM Behnam, C Steuer, CD Klein - Antiviral research, 2012 - Elsevier

... protease was assayed using the substrate Boc-Val-Pro-Arg-AMC, purchased from Bachem
(Germany). ... DEN protease is apparently more sensitive to molecular changes in the retro-peptide
inhibitors. The semi retro-inverse peptides 4 and 5 and the fully retro-inverse derivative 6 ...

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