[HTML] Crystal structure of USP7 ubiquitin-like domains with an ICP0 peptide reveals a novel mechanism used by viral and cellular proteins to target USP7

[HTML] Crystal structure of USP7 ubiquitin-like domains with an ICP0 peptide reveals a novel mechanism used by viral and cellular proteins to target USP7

R Pfoh, IK Lacdao, AA Georges, A Capar… - PLoS …, 2015 - journals.plos.org

Herpes simplex virus-1 immediate-early protein ICP0 activates viral genes during early
stages of infection, affects cellular levels of multiple host proteins and is crucial for effective
lytic infection. Being a RING-type E3 ligase prone to auto-ubiquitination, ICP0 relies on

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