[HTML] A peptide uncoupling BDNF receptor TrkB from phospholipase Cγ1 prevents epilepsy induced by status epilepticus

[HTML] A peptide uncoupling BDNF receptor TrkB from phospholipase Cγ1 prevents epilepsy induced by status epilepticus

B Gu, YZ Huang, XP He, RB Joshi, W Jang… - Neuron, 2015 - Elsevier

Summary The BDNF receptor tyrosine kinase, TrkB, underlies nervous system function in
both health and disease. Excessive activation of TrkB caused by status epilepticus promotes
development of temporal lobe epilepsy (TLE), revealing TrkB as a therapeutic target for

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