Structural modeling of osteoarthritis ADAMTS4 complex with its cognate inhibitory protein TIMP3 and rational derivation of cyclic peptide inhibitors from the complex …

Structural modeling of osteoarthritis ADAMTS4 complex with its cognate inhibitory protein TIMP3 and rational derivation of cyclic peptide inhibitors from the complex …

W Zhang, B Zhong, C Zhang, Y Wang, S Guo, C Luo… - Bioorganic …, 2018 - Elsevier

The ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4) enzyme
is a matrix-associated zinc metalloendopeptidase that plays an essential role in the
degradation of cartilage aggrecan in arthritic diseases and has been recognized as one of …

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