Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway
M Lu, T Liu, Q Jiao, J Ji, M Tao, Y Liu, Q You… - European journal of …, 2018 - Elsevier
Induced protein degradation by PROTACs has emerged as a promising strategy to target
nonenzymatic proteins inside the cell. The aim of this study was to identify Keap1, a
substrate adaptor protein for ubiquitin E3 ligase involved in oxidative stress regulation, as a …
nonenzymatic proteins inside the cell. The aim of this study was to identify Keap1, a
substrate adaptor protein for ubiquitin E3 ligase involved in oxidative stress regulation, as a …
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