2018年3月11日星期日

Inhibition of Alzheimer's amyloid-β peptide aggregation and its disruption by a conformationally restricted α/β hybrid peptide

Inhibition of Alzheimer's amyloid-β peptide aggregation and its disruption by a conformationally restricted α/β hybrid peptide

A PaulKC NadimpallyT MondalK Thalluri… - Chemical …, 2015 - pubs.rsc.org
Insertion of an anthranilic acid in an amyloidogenic peptide sequence generates a novel
conformationally restricted α/β-hybrid peptide that inhibits amyloid formation of Aβ (1–40)
and disrupts preformed fibrillar aggregates in vitro. Such β-sheet breaker hybrid peptides


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