#Cyclicpeptides Synthesis, please contact me at eva@pepmic.com

Amide bond cyclization is frequently used for cyclic peptides. It has the advantage over disulfides that these are chemically more stable. Most often backbone-amide cyclized peptides are prepared via head-to-tail cyclization or side-chain-to-side-chain cyclization. Similar to Cys-Cys cyclization, some synthetic challenges are encountered with amide cyclizations. An important challenge with head-to-tail cyclizations is the fact that the peptide cyclization is often slow due to entropic reasons. This can lead to undesired side reactions like racemization or peptide capping by coupling reagents. Effective head-to-tail cyclization therefore requires thorough expertise with respect to the optimal cyclization reagent and cyclization conditions. Over the years Pepmic has developed deep experience and know-how regarding the synthesis strategies for amide cyclic peptides, resulting in very high success rates even for challenging peptides.

Contact information

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com

Alanine Scan Library Synthesis from Pepmic Co., Ltd

Alanine scanning libraries are designed to identify the specific amino acid residues responsible for the peptide's function, stability, and conformation. Alanine, the smallest chiral amino acid, is sequentially substituted for each non-alanine residue one at a time. Subsequently, corresponding change in epitope activity can be measured. Substitution of key amino acid residue(s) with alanine causes changes in epitope binding activity. This library enables quick determination of each individual amino acid's contribution to the peptide's functionality.

Please contact me at 

Eva He 
Pepmic Co., Ltd
eva@pepmic.com
www.pepmic.com

List of Peptide Modification from Pepmic

A powerful aspect of synthetic peptides is the ability to create peptides with the exact conformation or characteristics needed for a given application through the addition of modifications. The following peptide modifications are available at Pepmic Co., Ltd( please contact Eva He for ordering/inquiry at eva@pepmic.com):

Abbreviation:
CO-NH-PEG4-Azide
Z-NH
TQ2-NH
Tpa-NH
TNP-NH
TMT6-131-NH
TMT6-130-NH
TMT6-129-NH
TMT6-128-NH
TMT6-127-NH
TMT6-126-NH
Sulfo-LC-SPDP
Succinyl-NH
Succinimidyl-NH
Succinimidyl-NH
Stearyl-NH
SAMSA-NH
Rhodamin B-NH
QSY21-NH
Propargyl-NH
PEG 20,000-NH
Palmitoyl-NH
Paa-NH
OVA-NH
NBD-NH
Naphtyl-NH
N3-PEG4-NH
Myristoyl-NH
MTS-NH
MS(PEG)24-NH
MS(PEG)12-NH
Mpa-NH
MCA-NH
MAP 8
MAP 4
MAP 16
Maleimide-NH
Maleimide-NH
KLH-NH
K(MOC)
IH2C-CO-
HRP-NH
H3C-O-CO-CH2-CH2-CO-NH
H2N-O-CH2-CO-NH
H2N-NH-CO-CH2-CH2-CO-NH-
Formyl-NH
Fmoc-NH
FITC-NH
DYQ 660-NH
DyLight 683Q-NH
DyLight 554-R1-NH
DyLight 550-NH
DyLight 543Q-NH
DyLight 504Q-NH
DY650-NH
DY630-NH
DY 800-NH
DY 776-NH
DY 751-NH
DY 750-NH
DY 682-NH
DY 680-NH
DY 649-NH
DY 649-NH
DY 647-NH
DY 647-NH
DY 635-NH
DY 633-NH
DY 549-NH
DY 547-NH
DY 530-NH
DY 505-NH
DY 495-NH
DY 488-NH
DNP-NH-G
DNP-NH
Digoxigenin-NH
Desthiobiotin-NH
Decanoyl-NH
DBCO-NH
Dansyl-NH
Dabsyl-NH
Dabcyl-NH
Cysteamide
Cy7-NH
Cy5.5-NH
Cy3-NH
CO-S(Bzl)
CO-Rhod 110
CO-pNA
CO-PEG 5000
CO-PAP
CO-OVA
COOtBu
COONp
COOMe
COOEt
CO-NHS
CO-NH-D-luciferin
CO-NH-CH2-CH2-NH-Biotin
CONH2
CO-NH(CH3)
CO-NH-(CH2-CH2-O)2-CH2-CH2-NH2
CONH(C2H5)
CO-NH -NH2
CO-NH -HRP
CO-NH -Blue Carrier Protein
CO-MCA
CO-KLH
CO-EDDnp
CO-EDANS
CO-DY 750
CO-DY 649P1
CO-DY 649P1
CO-DY 647
CO-DY 647
CO-DNP
CO-Dansyl
CO-BSA
CO-AMC
CO-AFC
CO- R-Phycoerythrin
CMK
Cinnamoyl-NH
CHO
BSA-NH
BrCH2CO-NH
Boc-NH
Biotin-SS-NH
Biotin-NH
BHQ1-NH
Benzoyl-NH
ATTO 647N-NH
ATTO 590-NH
ATTO 565-NH
ATTO 550-NH
ATTO 488-NH
Aminobicycloheptane carbox.ac.
Alexa 680-NH
Alexa 647-NH
Acetyl-NH
Acetyl-NH
6-TAMRA-NH
6-Fluorescein-NH
5-TAMRA-NH
5-Fluorescein-NH
5-Azidopentanoyl-NH
5/6-TAMRA-NH
5/6-Fluorescein-NH
4-Pentynoic acid-NH
2-Furoyl-NH
1-Adamantanecarbonyl-NH
[¦Ã-E]
[¦Â-A]
[Y(SO3H)]
[Y(PO3H2)]
[Y(Palm)]
[Y(NO2)]
[Y(N-Me)]
[Y(Me2)]
[Y(I)2]
[Y(D4)]
[Y(Cl)]
[Y(13C9; 15N)]
[Y (13C9; 15N)]
[X]
[W(OH)]
[W(Cl)]
[W(5-OH)]
[W(1-Me)]
[W (13C11;15N2)]
[V(N-Me)]
[V(Me)2]
[V(13C5; 15N)]
[V(13C5)]
[Tyr(t-Bu)]
[Tyr(Bzl)]
[TTDS]
[Tic]
[Thz]
[thioP]
[T(¦Â-GlcNAc)]
[T(¦Â-GlcNAc)]
[T(¦Á-Mannosyl)]
[T(¦Á-GalNAc)]
[T(SO3H)]
[T(PO3H2)]
[T(13C4;15N)]
[Sta]
[Sec]
[S(¦Â-GlcNAc)]
[S(¦Á-Mannosyl)]
[S(¦Á-GalNAc)]
[S(SO3H)]
[S(PO3H2)]
[S(Oct)]
[S(D3)]
[S(Ac)]
[S (13C3;15N)]
[R(Me3)]
[R(Me)2-sym]
[R(Me)2-asym]
[R(Me)]
[R(Boc)2]
[R(13C6; 15N4)]
[R(13C6)]
[Q(13C5;15N2)]
[Pyr]
[Propargylala]
[Pra]
[Pip]
[Photo-M]
[Photolabile linker]
[Photo-L]
[Phg]
[Phe(4-CN)]
[Pen]
[PEG 8]
[PEG 6]
[PEG 5000]
[PEG 5]
[PEG 4]
[PEG 3500]
[PEG 3]
[PEG 2000]
[PEG 2]
[PEG 12]
[para-Ac-Phe]
[P(Me2)]
[P(2-Me)]
[P(13C5; 15N)]
[Orn]
[Orn(C343)]
[Orn(Biotin)]
[Oic]
[Nva]
[Nle]
[Nle(N3)]
[N(¦Â-GlcNAc)]
[N(13C4; 15N2)]
[Mpa]
[Mercaptoacetyl]
[M(O2)]
[M(O)]
[Lys(NMA)]
[L-3-Abu]
[L-2-Abu]
[L(N-Me)]
[L(D3)]
[L(D10)]
[L(13C6; 15N)]
[L(13C6)]
[L(13C1)]
[Kyn]
[K]
[K]
[K]
[K(TFA)]
[K(Succinyl)]
[K(Stearyl)]
[K(Rhodamine Green)]
[K(Rhodamine B)]
[K(Pyrofolate)]
[K(Propionyl)]
[K(Propionyl)]
[K(NIP)]
[K(N3)]
[K(Me)3]
[K(Me)2]
[K(Me)]
[K(MCA)]
[K(Lipoyl)]
[K(KLH]
[K(HOMCA)]
[K(HOMCA)]
[K(HOC)]
[K(Glutaryl)]
[K(GGRLR)]
[K(GG)]
[K(Formyl)]
[K(FITC)]
[K(Ferrocene)]
[K(DYQ 660)]
[K(DYQ 3)]
[K(DyLight 633)]
[K(DY 800)]
[K(DY 650)]
[K(DY 649)]
[K(DY 647)]
[K(DY 635)]
[K(DY 630)]
[K(DY 590)]
[K(DY 547)]
[K(DY 530)]
[K(DY 495)]
[K(DY 488)]
[K(DY 405)]
[K(DST-PEG 2-Biotin)]
[K(DNP)]
[K(Digoxigenin)]
[K(Desthiobiotin)]
[K(Dde)]
[K(Dabsyl)]
[K(Dabcyl)]
[K(Butyryl)]
[K(BSA]
[K(Boc)]
[K(Biotin)]
[K(BHQ2)]
[K(ATTO 680)]
[K(ATTO 655)]
[K(ATTO 488)]
[K(Aoa)]
[K(Ahx-SS-Biotin)]
[K(Ahx-Biotin)]
[K(Ahx-(5-Fluo))]
[K(Ac)]
[K(6-Fluo)]
[K(5-TAMRA)]
[K(5-Fluo)]
[K(5/6-TAMRA)]
[K(5/6-Fluo)]
[K(13C6; 15N2)]
[K(13C6)]
[iso-Val]
[isoAsp]/[beta-Asp]
[iso-Asp]
[Igl]
[I(13C6; 15N)]
[Hyp]
[Hpu]
[Homotrp]
[Homoser]
[Homoser lactone]
[Homopro]
[Homophe]
[HomoF]
[Homocit]
[Hnv]
[His(15N3)]
[H-DL-Hyl]
[HCys]
[Hcy]
[H3C-S-CH2-CH2-CO-CO-NH]
[H(DNP)]
[Glu(Arg)]
[Gla]
[Gla amide]
[gamma-E]
[G(tBu)]
[G(N-Me)]
[G(cyclopentyl)]
[G(CHO)]
[G(allyl)]
[G(13C2; 15N)]
[Formyl-Kyn]
[F(PO3H2)]
[F(OH)2]
[F(NO2)]
[F(N-Me)]
[F(N3)]
[F(Me)2]
[F(I)]
[F(4-Cl)]
[F(13C9; 15N)]
[E(¦Á-Me)]
[E(OMe)]
[E(EDANS)]
[E(13C5; 15N)]
[E cyclo(E-K) ]
[D-W(2-Me)]
[D-R(Boc)2]
[D-Pra]
[DPA(DY-647)]
[DPA(DY-647)]
[DPA(DY 488)]
[DOTA]
[D-Orn]
[DOPA]
[D-K(5/6-TAMRA)]
[D-K(5/6-Fluorescein)]
[D-iso-Val]
[D-Igl]
[D-Hpg]
[D-Homoser]
[D-Homocys]
[D-His(Trt)]
[D-HCys]
[D-Glu amide]
[D-gamma-Glu]
[D-F(4-Br)]
[D-Dab]
[D-Cha]
[D-C(2-Mercaptopyridine)]
[DAP]
[DAP(NMA)]
[DAP(DNP)]
[D-Agb]
[D-aa]
[D-3-Abu]
[D-2-Nal]
[D-2-Abu]
[D-1-Nal)]
[D/L-W(Br)]
[D(¦Á-Me)]
[D(OMe)]-FMK
[D(OMe)]
[D(Isopropylamide)]
[D(13C4; 15N)]
[D cyclo(D-K)]
[Cys(DYQ660)]
[Cys cyclo(S-S)]
[Cya]
[Cit]
[Cha]
[Cav]
[C(TF2)]
[C(S-tert-But]
[C(S-Prop)]
[C(S-Pentyl)]
[C(SO3H)]
[C(S-Me)]
[C(S-Isoprop)]
[C(S-Isobut)]
[C(S-Et)]
[C(S-But)]
[C(PEG-KLH)]
[C(PEG4-DBCO)]
[C(PEG 40000)]
[C(Pam2)]
[C(Palm)]
[C(OVA)]
[C(Npys)]
[C(Myristyl)]
[C(MTSL)]
[C(Mmt)]
[C(KLH)]
[C(HRP)]
[C(Farnesyl)]
[C(DyLight 488)]
[C(DY 649)]
[C(DY 647P1)]
[C(DY 555)]
[C(DBCO)]
[C(Cmc)]
[C(Cam)]
[C(BSA)]
[C(ATTO 680)]
[C(Allophycocyanine)]
[C(AEDANS)]
[C(Acm)]
[C(acetamido-fluorescein)]
[C(6-TAMRA)]
[C(5-TAMRA)]
[C(5/6-TAMRA)]
[C(2-Mercaptopyridine)]
[C cyclo(S-S)]
[C cyclo(S-S)]
[C cyclo(S-S)]
[C cyclo(S-S)]
[Aze]
[Aza]
[Ava]
[Aoc]
[ANP]
[Amino nitrophenyl prop. acid]
[Allyl-G]
[Allyl-A]
[Ala(N-Me)]
[Ala(2-Bacd)]
[Aib]
[Ahx]
[Aha]
[Agp]
[Agb]
[Ado]
[Ac6c]
[Ac3c]
[Abz]
[Abu]
[Aad]
[A(pentenyl)]
[A(MCA)]
[A(F2)]
[A(D3)]
[A(3,3-Phenyl)]
[A(13C3; 15N)]
[4-Abz]
[4-Abu]
[3-Nitro-Pyrrol]
[3-Nitro-Indole]
[3-Abz]
[2-Nal]
[2-Me-Trp]
[2-Amino-4-thiazolinyl]
[2-Aib]
[2-Abz]
[1-Nal]
[12-Ado]
[1,4-trans-ACHC]
[1,4-cis-ACHC]
[1,3-cis-ACHC]
[1,2-trans-ACHC]
[1,2-cis-ACHC]
(dY)
(dW)
(dVC)
(dT)
(dS)
(dR)
(dQ)
(dP)
(dN)
(dM)
(dL)
(dK)
(dI)
(dH)
(dF)
(dE)
(dD)
(dC)
(dA)

Full Name

PEG4-Azide

Cyclisation (D-K), amide bond -

Cyclisation (E-K), amide bond -

Side chain coupling to Lys

Propargylalanine

Cyclisation (K-C-terminus) - side chain of K to C-terminus

Propargyl

Hetero-Dimer-

Homo-Dimer-

Azidohomoalanine - Aha/ Dab(N3)

3-Azido-Alanine - Aza

Cyclisation (C-C), disulfide -

Double disulfide bridge -

Cyclisation (Dab-C-Terminus)

Triple disulfide -

Site directed disulfide bridge - Cyclisation (C-C)

Cyclisation (Cys-N-terminus)

Cyclisation (Orn-C-Terminus)

D-Propargylglycine - D-Pra

para-Azido-Phenylalanine -

Cys(PEG4-Dibenzocyclooctyne)

Azido-Lysine -

Side chain coupling to Lys - Asymmetric Sequence

Cyclisation (Cys-C-terminus)

Cyclisation (Cys-Cys)

Side chain coupling to Lys - Symmetric Sequence

6-Azido-Norleucine - Nle(N3)

Propargylglycine - Pra

Mixed amino acids -

5-Azidopentanoyl - 

Cyclisation (NH-CO), homodetic -

R-Phycoerythrin -

Amino-trifluoromethyl-coumarin - AFC

7-Amino-4-methylcoumarin - AMC

Dansyl -

2,4-Dinitrophenyl - DNP

Alexa 647

Alexa 680

Ala(MCA)

Amino-D-luciferin

DY 647 - aminomodified

Cys(DyLight 488)

DY 750 -

EDANS -

Cys(Tide Fluor 2)

Cys(ATTO 680)

Dinitrophenyl-Ethylenediamine - EDDnp

Methoxycoumarin acetic acid - MCA

BHQ1

para-Nitroanilide - pNA

Rhodamine 110 -

para-Nitrophenylester -

Ala(2-Bacd) - benzo[b]acridin-12(5H)-on-2-yl

Cys(5-TAMRA) -

Cys(5/6-TAMRA) -

Cys(6-TAMRA) -

Dibenzocylooctyl

Cys(acetamido-fluorescein) -

Cys(acetamido EDANS)

Cys(Allophycocyanine) -

Cys(DY 555) -

Cys(DY 647P1) -

DY 647P1

DY 647P1

DAP(DY 647P1)

Cys(DY 649P1)

Cys(DYQ660) -

D-Lys(5/6-Fluorescein) -

D-Lys(5/6-TAMRA) -

DAP(DNP) - DNP at Diaminopropionic acid

DAP(NMA) - NMA at Diaminopropionic acid

DAP(DyLight 488) - DyLight 488 at Diaminoprop. ac

DAP(DY 647) - DY 647 at Diaminopropionic ac.

Glu(EDANS) -

His(DNP) -

Lys(5-Fluorescein) -

Lys(5-TAMRA) -

Lys(5/6-Fluorescein) -

Lys(5/6-TAMRA) -

Lys(6-Fluorescein) -

Lys(Ahx-(5-Fluorescein)) -

Lys(ATTO 655) -

Lys(Dabcyl) -

Lys(2,4-DNP) -

Lys(DY 405) -

Lys(DyLight 488) -

Lys(ATTO 488)

Lys(DY 495) -

Lys(DY 530) -

Lys(ATTO 680)

Lys(DY 547) -

Lys(BHQ2)

Lys(DY 590) -

Lys(DY 630) -

Lys(DY 635) -

Lys(DY 647) -

Lys(Dabsyl)

Lys(DyLight 649) -

DY 776

Lys(DY 800) -

Lys(DyLight 633) - Lys(DY633)

Lys(HOMCA)

ATTO 488

Lys(DYQ 3) -

DY 649P1

DY 649P1

Lys(MCA) -

Lys(Rhodamine B) -

Lys(Rhodamine Green) -

Lys(Dde) -

Lys(DY 650) -

Lys(HOC)

ATTO 565

Lys(HOMCA) -

ATTO 550

ATTO 590

Lys(DYQ 660)

Lys(2-(N-methylamino)benzoyl) - Lys(NMA)

Ornithine(Coumarin343) -

DY 650 -

Lys(FITC)-

FITC-

Lys(MOC) - (7-methoxycoumarin-3-yl)formyl

5-Carboxyfluorescein - 5-FLUO

5-Tetramethylrhodamine - 5-TAMRA

5/6-Carboxyfluorescein - 5/6-FLUO

5/6-Tetramethylrhodamine - 5/6-TAMRA

6-Carboxyfluorescein - 6-FLUO

6-Tetramethylrhodamine - 6-TAMRA

ATTO 647N -

DY 649P1 - aminomodified

Cy7 -

Cy3 -

Cy5.5 -

Dabcyl -

Dabsyl -

Dansyl -

2,4-Dinitrophenyl - DNP

(2,4-Dinitrophenyl)-Glycine - (2,4-DNP)-Gly

DyLight 488 -

DyLight 550

DY 495 -

DY 505 -

DY 530 -

DY 547 -

DY 549 -

DY 633 -

DY 635 -

DY 647 -

DY 649 -

DY 680 -

DY 682 -

DY 750 -

DY 751 -

DY 800 -

DY 630 -

DyLight 504Q -

DyLight 543Q -

DyLight 554-R1 -

DyLight 683Q -

DYQ 660 -

Methoxycoumarin acetic acid - MCA

QSY21 -

Rhodamine B -

Tide Quencher 2 - TQ2

BSA -

KLH -

Blue Carrier Protein -

OVA -

MAP 16 - Crude 8-20 aa, at C-term. only

MAP 4 - Crude 8-20 aa, at C-term. only

MAP 8 - Crude 8-20 aa, at C-term. only

Cys(PEG-KLH)

Cys(BSA) -

Cys(KLH) -

Cys(DBCO)

Cys(OVA) -

Lys(BSA) -

OVA via Glutaraldehyde

Lys(KLH) -

BSA via Glutaraldehyde -

KLH via Glutaraldehyde -

Heavy Ala (13C3;15N) -

Heavy Ala (D3) -

Heavy Asp (13C4;15N -

Heavy Glu (13C5;15N) -

Heavy Phe (13C9;15N) -

Heavy Gly (13C2;15N) -

Heavy His (15N3) -

Heavy Ile (13C6;15N) -

Heavy Lys (13C6) -

Heavy Lys (13C6;15N2) -

Heavy Leu (13C1) -

Heavy Leu (13C6) -

Heavy Leu (13C6;15N)?

Heavy Leu (D10) -

Heavy Leu (D3) -

Heavy Asn (13C4;15N2) -

Heavy Pro (13C5;15N) -

Heavy Gln (13C5;15N2) -

Heavy Arg (13C6) -

Heavy Arg (13C6;15N4) -

Heavy Ser (13C3;15N) -

Heavy Ser (D3) -

Heavy Thr(13C4;15N) -

Heavy Tyr (13C9;15N)

L-tyrosine-phenyl-d4 - deuterated Tyr

Heavy Val (13C5) -

Heavy Val (13C5;15N) -

Heavy Trp (13C11;15N2) -

Heavy Tyr (13C9;15N) -

TMT6-126 -

TMT6-127 -

TMT6-128 -

TMT6-129 -

TMT6-130 -

TMT6-131 -

12-Aminododecanoic acid

L-2-Aminobutyric acid

4-Amino butyric acid

2-Aminoisobutyric acid

PEG 5000 -

12-Aminododecanoic acid - Ado

6-Aminohexanoic acid (Ahx) - Aminocaproic acid (Aca)

8-Aminooctanoic acid - Aoc

5-Aminopentanoic acid - Aminovaleric acid (Ava)

Cys(PEG 40000) -

PEG 12 (40 atoms) - Amino-PEG-acid

PEG 2000 - Amino-PEG-acid

PEG 2 (9 atoms) - 8-Amino-3,6-dioxaoctanoic acid

PEG 3 (13 atoms) - Amino-trioxadodecanoic acid

PEG 4 (16 atoms) - Amino-PEG-acid

PEG 5000 - Amino-PEG-acid

PEG 3500 - Amino-PEG-acid

PEG 5 (19 atoms) - Amino-PEG-acid

PEG 6 (22 atoms) - Amino-PEG-acid

PEG 8 (28 atoms) - Amino-PEG-acid

Sulfo-LC-SPDP

Photolabile linker

Methyl-PEG12 - MS(PEG)12

Methyl-PEG24 - MS(PEG)24

PEG-4 Azide -

PEG 20,000 -

Homoserine lactone -

Aldehyde -

Chlormethylketon - CMK

HRP -

Hydrazide -

Methylamide - N-Methyl

Bis(aminoethyl)ethylene glycol -

Biotin - Ethylenediamin-Biotin

N-Hydroxysuccinimid ester - NHS

4-Phenylazophenol - O-PAP

Thiobenzyl -

Ethylamide - N-Ethyl

Amidation -

Ethylester - O-Ethyl

Methylester - O-Methyl

t-Butylester -

Cysteamide -

3-Nitro-Indole -

3-Nitro-Pyrrol -

Amino nitrophenyl prop. acid -

Amino-nitrophenyl propion. ac. - ANP-linker

Cys(Acetamidomethyl) - Cys(Acm)

Cys(Carbamidomethyl) - Cys(CAM) / Cys(CH2CONH2)

Cys(Carboxymethyl) - Cys(CMC) / Cys(CH2COOH)

Cys(Farnesyl) -

Cys(HRP) - Cys(horseradish peroxidase)

Cys(4-Methoxytrityl) - Cys(MMT)

Cys(MTSL) -

Cys(Myristyl) - Cys(CH2(CH2)12CH3)

3-nitro-2-pyridylthio-L-Cys -

Cys(Palmitoyl) -

Cys(di(palmitoyloxy)-propyl) - Cys(Pam2)

Cys(S-Butyl) -

Cys(S-Ethyl) -

Cys(S-Isobutyl) -

Cys(S-Isopropyl) -

Cys(S-Methyl) -

Cys(S-Pentyl) -

Cys(S-Propyl) -

Cys(S-tert-Butyl) -

para-Bromo-D-Phenylalanine -

6-Bromo-D/L-Tryptophan -

para-Chloro-Phenylalanine -

para-Iodo-Phenylalanine -

para-Nitro-Phenylalanine -

Glu(Arg) - Arg at side chain of Glu

Lys(Acetyl) -

Lys(Ahx-Biotin) -

Lys(Ahx-SS-Biotin) -

Lys(2-Aminooxy acetic acid) - Lys(Aoa)

Lys(Biotin) -

Lys(Boc) -

Lys(Butyryl) -

Lys(Desthiobiotin) -

Lys(Digoxigenin] -

Lys(DST-PEG 2-Biotin) -

Lys(Ferrocene) -

Lys(Formyl) -

Lys(GG) - Ubiqutin

Lys(GGRLR) -

Lys(Glutaryl) -

Lys(Lipoyl) -

Lys(NIP) -

Lys(Palmitoyl) -

Lys(Propionyl) -

Lys(Pyrofolate) -

Lys(Stearyl) -

Lys(Succinyl) -

Lys(TFA) - Lysine(Trifluoracetyl)

Orn(Biotin) -

Photo-Leucine -

Photo-Methionine -

Ser(Acetyl) -

Ser(Octanoyl) -

6-Cloro-Tryptophan -

3-Chloro-Tyrosine -

3,5-Diiodo-Tyrosine -

3-Nitro-Tyrosine -

Tyr(Palmitoyl) -

1-Adamantanecarbonyl -

2-Furoyl -

4-Pentynoic acid -

DOTA -

4-Methylthio-2-oxobutanoic ac. -

p-tosyl-Gly -

Succinimidyl via DSC

Succinimidyl via DSS

Acetylation -

Benzoyl - Bz

Biotin -

Biotin-SS-linker -

tert. Butoxycarbonyl - Boc

Brom acetic acid -

trans-Cinnamoyl -

Decanoyl -

Desthiobiotin -

Digoxigenin -

Fmoc -

Formyl -

Hydrazine-succinyl -

Aminooxyacetyl -

Methoxysuccinyl -

HRP -

Iodoacetyl -

3-(Maleimido)propionyl -

Maleimide - via SMCC

Methanethiosulfonate - MTS

Myristoyl -

2-Naphtoic acid -

4-nitrobenzo-2-oxa-1,3-diazole - NBD

Phenylacetic acid - Paa

Palmitoyl -

S-Acetylmercaptosuccinyl - SAMSA

Stearyl -

Succinyl -

2,4,6-Trinitrophenyl - TNP

Thiopropionyl - Tpa

Benzyloxycarbonyl - Cbz, Z

2-Methyl-Tryptophan -

N-Methyl-Alanine -

¦Á-Methyl Aspartic acid -

¦Á-Methyl Glutamic acid -

Dimethyl-Phenylalanine -

N-Methyl-Phenylalanine -

Phosphono-Phenylalanine -

N-Methyl-Glycine -

Dimethyl-Lysine -

Trimethyl-Lysine -

Methyl-Lysine -

N-Methyl-Leucine -

¦Â-GlcNAc-Asparagine -

2-Methylproline -

Dimethyl-Cysteine - Penicillamine

Dimethyl-Arginine (asym.) -

Dimethyl-Arginine (sym.) -

Methyl-Arginine -

Trimethyl-Arginine -

Phospho-Serine -

Sulfuryl-Serine -

¦Á-GalNAc-Serine -

¦Á-Mannosyl-Serine -

¦Â-GlcNAc-Serine -

Phospho-Threonin -

Sulfuryl-Threonine -

¦Á-GalNAc-Threonine -

¦Á-Mannosyl-Threonine -

¦Â-GalNAc-Threonine -

¦Â-GlcNAc-Threonine -

Dimethyl-Valine -

N-Methyl-Valine -

1-Methyl-Tryptophan -

2,6-Dimethyl-Tyrosine -

N-Methyl-Tyrosine -

Phospho-Tyrosin -

Sulfuryl-Tyrosine -

D-Alanine -

D-Cysteine -

D-Aspartic acid -

D-Glutamic acid -

D-Phenylalanine -

D-Histidine -

D-Isoleucine -

D-Lysine -

D-Leucine -

D-Methionine -

D-Asparagine -

D-Proline -

D-Glutamine -

D-Norarginine

D-Arginine -

D-Arg(Boc)2

D-Serine -

D-Cys(2-Mercaptopyridine)

D-Homocysteine

D-Threonine -

D-Valine -

D-Histidine(Triphenylmethyl)

D-Tryptophan -

D-Tyrosine -

Aminoisobutyric acid - Aib

Isoaspartic acid -

2-Amino-4-thiazolinic acid -

2-Naphthyl-Alanine - 2-Nal

2-Aminobenzoic acid

3,3-Diphenyl-Alanine -

2-(4'-Pentenyl)alanine -

alpha-aminoadipic acid - Aad

Aminobutyric acid - Abu

Aminobenzoic acid - Abz

Aminocyclohexyl carbox. acid - Ac6c

alpha-Allylalanine -

Azetidine-2-carboxylic acid - Aze

Cysteine sulfonate -

Canavanine - Cav

¦Â-Cyclohexyl-Alanine - Cha

2-amino-3-hydroxypentanoic ac.

3-exo-aminobicyclo[2.2.1]-

3,3-Diphenyl-Alanine

Citrulline -

Allyl-Glycine

5-Hydroxy-Tryptophan

4-Aminobenzoic acid

3,4-Dihydroxy-Phenylalanine

Aminocyclopropane carb. ac.

Arg(Boc)2

D-2-Aminobutyric acid

D-2,4-Diamino-butyric acid

3-Aminobenzoic acid

2-Amino-3-guanidinoprop. acid

Asp beta-methyl ester- FMK

beta-Homoproline

Cysteic acid - Cya

D-Isovaline

Asp(Isopropylamide) -

D-3-Aminobutyric acid

Asp beta-methyl ester - Asp(OMe)

2-Naphthyl-D-Alanine - D-2-Nal

D-Amino Acid -

¦Â-cyclohexyl-D-Alanine - D-Cha

D-Homocysteine -

D-Homoserine -

Cys(2-Mercaptopyridine)

D-4-Hydroxyphenly-Glycine - D-Hpg

D-2-Indanyl-Glycine - D-Igl

D-Ornithine -

2-Methyl-D-Tryptophan -

2,3-Diaminopropionic acid - DAP

Glu gamma-methyl ester - Glu(OMe)

3,4-Dihydroxy-Phenylalanine -

N-Formylkynurenine -

Allyl-Glycine - 2-Aminopent-4-enoic acid

Formylglycine -

Cyclopentyl-Glycine -

alpha-t-butylglycine -

Gamma-Glu, amidated - Gla, amidation at side chain

gamma-Carboxyglutamic acid - Gla

Homo-Citrulline -

Homophenylalanine -

Homoserine -

gamma-D-Glu, amidated

Hyposine - Hpu

Isoaspartic acid

L-3-Aminobutyric acid

Isovaline

Norarginine

Homophenylalanine

Hydroxy-Proline - Hyp

Mercaptopropionyl

Homotryptophane

O-Benzyl-Tyrosine

H-DL-delta-Hydroxy-DL-Lys

gamma-D-Glutamic acid

2-Indanyl-Glycine - Igl

Kynurenine - Kyn

p-Cyanophenylalanine

Homocysteine

Methionine-sulfoxide -

Methionine-sulfone -

Pipecolic acid

gamma-Glutamic acid

Mercaptoacetic acid - Thioglycolic acid

Statine

Mercaptopropionic acid - Mpa

Norleucine -

Norvaline - 2-Aminopentanoic acid, Nva

Thioproline

Tyr(t-Bu)

Octahydroindole carbox. acid -

Ornitine -

5,5-Dimethyl-Proline -

para-Acetylphenylalanine - pAF

Phenylglycine - Phg

Pyroglutamic acid - Pyr

Selenocysteine - Sec

Thiazolidine-4-carboxylic acid - Thz

Tetrahydroisquinol.carb.acid - Tic

Diaminotrioxatridecan suc. ac. - TTDS

5-Hydroxy-Tryptophan -

¦Â-Alanine -

1,2-trans-ACHC

1,4-trans-ACHC

1-Naphthyl-D-Alanine

1-Naphthyl-Alanine

1,4-cis-ACHC

1,3-cis-ACHC

1,2-cis-ACHC

¦Ã-Glutamic acid -

Homocysteine-

For peptide synthesis ordering/inquiry, please contact me at

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com