2017年4月7日星期五

C-terminal Peptide Modifications from Pepmic

A wide range of C terminal modifications are available in Pepmic. The default C-terminus of a peptide is either a free carboxylic acid or an amide. C-terminal amidation removes the charge form the C-terminus of a peptide. This may reduce the overall solubility of the peptide. The uncharged C-terminal amide end more closely mimics the native protein, and therefore may increase the biological activity of a peptide. It also tends to increase the stability, and prolongs their shelf life. Frequently applied C-terminal modifications are shown in the table below.
p-Nitroanilide(pna)
N-alkyl Amides
N-alkyl amides
Esters ome
Esters oet
Amidation
Aldehyde
7-Amino-4-Methylcoumarin (AMC)

Eva He
eva@pepmic.com
www.pepmic.com










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