Leptin stimulates both endothelin-1 and nitric oxide activity in lean subjects but not in patients with obesity-related metabolic syndrome

Leptin stimulates both endothelin-1 and nitric oxide activity in lean subjects but not in patients with obesity-related metabolic syndrome

F Schinzari, M Tesauro, V Rovella… - The Journal of …, 2013 - academic.oup.com

... To this purpose, after the forearm was instrumented, baseline blood samples were collected and
normal saline was given intraarterially for 15 minutes, at which point an infusion of BQ-123
(Bachem, Bubendorf, Switzerland), a selective antagonist of ET A receptors, was started ...

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