2018年4月30日星期一

Phase I study of glypican-3-derived peptide vaccine therapy for patients with refractory pediatric solid tumors

Phase I study of glypican-3-derived peptide vaccine therapy for patients with refractory pediatric solid tumors

N Tsuchiya, A Hosono, T Yoshikawa, K Shoda… - …, 2018 - Taylor & Francis
The carcinoembryonic antigen glypican-3 (GPC3) is a good target of anticancer
immunotherapy against pediatric solid tumors expressing GPC3. In this non-randomized,
open-label, phase I clinical trial, we analyzed the safety and efficacy of GPC3-peptide  …


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Effects of different force fields on the structural character of α synuclein β-hairpin peptide (35–56) in aqueous environment

Effects of different force fields on the structural character of α synuclein β-hairpin peptide (35–56) in aqueous environment

S Kundu - Journal of Biomolecular Structure and Dynamics, 2018 - Taylor & Francis
The hallmark of Parkinson's disease (PD) is the intracellular protein aggregation forming
Lewy Bodies (LB) and Lewy neuritis which comprise mostly of a protein, alpha synuclein (α-
syn). Molecular dynamics (MD) simulation methods can augment experimental techniques …



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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
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Pepmic Co., Ltd
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miR-204 controls Glucagon-like Peptide 1 Receptor expression and agonist function

miR-204 controls Glucagon-like Peptide 1 Receptor expression and agonist function

SH Jo, J Chen, G Xu, TB Grayson, LA Thielen… - Diabetes, 2018 - Am Diabetes Assoc
Glucagon-like peptide 1 receptor (GLP1R) agonists are widely used to treat diabetes.
However, their function is dependent on adequate GLP1R expression, which is
downregulated in diabetes. GLP1R is highly expressed on pancreatic β-cells, and activation …


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
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T cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy

T cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy

EM Doorduijn, M Sluijter, KA Marijt, BJ Querido… - …, 2018 - Taylor & Francis
Cancers frequently evade immune-recognition by lowering peptide: MHC-I complexes on
their cell surface. Limited peptide supply due to TAP-deficiency results in such MHC-Ilow
immune-escape variants. Previously, we reported on a category of TAP-independent self …


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
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Validation of immunomonitoring methods for application in clinical studies: The HLA‐peptide multimer staining assay

Validation of immunomonitoring methods for application in clinical studies: The HLA‐peptide multimer staining assay

PA Chandran, K Laske, A Cazaly… - Cytometry Part B …, 2018 - Wiley Online Library
Background Validated assays are essential to generate data with defined specificity,
consistency, and reliability. Although the process of validation is required for applying
immunoassays in the context of clinical studies, reports on systematic validation of in vitro T …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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Pepmic Co., Ltd
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Redox sensitive PEG controlled octaarginine and targeting peptide co-modified nanostructured lipid carriers for enhanced tumour penetrating and targeting in vitro …

Redox sensitive PEG controlled octaarginine and targeting peptide co-modified nanostructured lipid carriers for enhanced tumour penetrating and targeting in vitro …

H Wang, M Sun, D Li, X Yang, C Han… - Artificial cells …, 2018 - Taylor & Francis
To strengthen the anti-tumour efficacy and weaken the side effects, a nano targeted drug
delivery system was constructed. The nanostructured lipid carriers (NLCs) were prepared by
the melt-emulsification method. Modified with the octaarginine, thiolytic cleavable …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
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Comparison of carbohydrate antigen 125 and N-terminal pro-brain natriuretic peptide for risk prediction after transcatheter aortic valve implantation

Comparison of carbohydrate antigen 125 and N-terminal pro-brain natriuretic peptide for risk prediction after transcatheter aortic valve implantation

T Rheude, C Pellegrini, H Schmid… - American journal of …, 2018 - ajconline.org
Elevated carbohydrate antigen 125 (CA125) and N-terminal pro-brain natriuretic peptide 
(NTproBNP) have been associated with adverse outcome after transcatheter aortic valve
implantation (TAVI). This study performs a comparison of both biomarkers for prognosis after …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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Persistent Hematologic Dysfunction after Peptide Receptor Radionuclide Therapy with 177Lu-DOTATATE: Incidence, Course, and Predicting Factors in Patients with …

Persistent Hematologic Dysfunction after Peptide Receptor Radionuclide Therapy with 177Lu-DOTATATE: Incidence, Course, and Predicting Factors in Patients with …

H Bergsma, K van Lom… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Peptide receptor radionuclide therapy (PRRT) may induce long-term toxicity to the bone
marrow (BM). The aim of this study was to analyze persistent hematologic dysfunction (PHD)
after PRRT with 177 Lu-DOTATATE in patients with gastroenteropancreatic neuroendocrine …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
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Pepmic Co., Ltd
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Racial differences in plasma levels of N-terminal pro–B-type natriuretic peptide and outcomes: the Reasons for Geographic and Racial Differences in Stroke …

Racial differences in plasma levels of N-terminal pro–B-type natriuretic peptide and outcomes: the Reasons for Geographic and Racial Differences in Stroke …

NS Bajaj, OM Gutierrez, G Arora, SE Judd… - JAMA …, 2018 - jamanetwork.com
Importance Recent studies have suggested that the natriuretic peptide system may be
endogenously suppressed in black individuals who are free of prevalent cardiovascular
disease. Whether natriuretic peptide levels contribute to racial disparities in clinical …


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*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
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Pepmic Co., Ltd
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A novel GIP analogue, ZP 4165, enhances glucagon‐like peptide‐1‐induced body weight loss and improves glycaemic control in rodents

A novel GIP analogue, ZP 4165, enhances glucagon‐like peptide‐1‐induced body weight loss and improves glycaemic control in rodents

PK Nørregaard, MA Deryabina… - Diabetes, Obesity …, 2018 - Wiley Online Library
Aim To investigate the effects of the novel glucose‐dependent insulinotropic polypeptide
(GIP) analogue, ZP 4165, on body weight and glycaemic control in rodents, and to
investigate if ZP 4165 modulates the anti‐obesity and anti‐hyperglycaemic effects of a …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


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2018年4月29日星期日

Self-assembling Peptide P11-4 and Fluoride for Regenerating Enamel

Self-assembling Peptide P11-4 and Fluoride for Regenerating Enamel

M Alkilzy, A Tarabaih, RM Santamaria… - Journal of dental …, 2018 - journals.sagepub.com
Regenerative medicine-based approaches for caries treatment focus on biomimetic
remineralization of initial carious lesions as a minimal invasive therapy. In vitro, self-
assembling peptide P11-4 enhances remineralization of early carious lesions. To …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
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[HTML] Humoral immunity profiling of subjects with myalgic encephalomyelitis using a random peptide microarray differentiates cases from controls with high …

[HTML] Humoral immunity profiling of subjects with myalgic encephalomyelitis using a random peptide microarray differentiates cases from controls with high …

S Singh, P Stafford, KA Schlauch, RR Tillett… - Molecular …, 2018 - Springer
Myalgic encephalomyelitis (ME) is a complex, heterogeneous illness of unknown etiology.
The search for biomarkers that can delineate cases from controls is one of the most active
areas of ME research; however, little progress has been made in achieving this goal. In …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
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