Quaternary β2,2‐Amino Acids: Catalytic Asymmetric Synthesis and Incorporation into Peptides by Fmoc‐Based Solid‐Phase Peptide Synthesis

Quaternary β^2,2‐Amino Acids: Catalytic Asymmetric Synthesis and Incorporation into Peptides by Fmoc‐Based Solid‐Phase Peptide Synthesis

JS Yu, H Noda, M Shibasaki - Angewandte Chemie, 2018 - Wiley Online Library

Abstract β‐Amino acid incorporation has emerged as a promising approach to enhance the
stability of parent peptides and to improve their biological activity. Owing to the lack of
reliable access to β2, 2‐amino acids in a setting suitable for peptide synthesis, most …

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