2020年1月2日星期四

Molecular dynamics simulations reveal the mechanism of graphene oxide nanosheet inhibition of Aβ 1–42 peptide aggregation

Molecular dynamics simulations reveal the mechanism of graphene oxide nanosheet inhibition of Aβ 1–42 peptide aggregation

Y Jin, Y Sun, Y Chen, J Lei, G Wei - Physical Chemistry Chemical …, 2019 - pubs.rsc.org
The aggregation of the amyloid-beta (Aβ) peptides into toxic β-sheet-rich oligomers,
protofibrils and mature fibrils is the major pathological hallmark of Alzheimer's disease (AD).
Inhibiting the β-sheet formation and fibrillization of Aβ peptides is considered an important …


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