CCR3 Antibody

Product	CCR3 Antibody
Cat#	100-6-03A
Unit/Weight	100 μg
Unit Price	$266.00
Species Reactivity	H, M, R
Tested Application(s)	E, WB
Brief Description	Pepmic offers CCR3 Antibody-1109 product,The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia.
Specific Description	Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells (1-4). CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS (3,4). High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems (5). The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia. These results indicate CCR3 plays an important role in HIV infection of CNS.
Storage	CCR3 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

CCR5 Antibody

Product	CCR5 Antibody
Cat#	100-6-04A
Unit/Weight	100 μg
Unit Price	$311.00
Species Reactivity	H
Tested Application(s)	E, WB, IHC
Brief Description	Pepmic offers CCR5 Antibody product,CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
Specific Description	Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The b-chemokines RANTES, MIP-1alpha and MIP-1beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
Storage	CCR5 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

CCR8 Antibody

Product	CCR8 Antibody
Cat#	100-6-05A
Unit/Weight	100 μg
Unit Price	$266.00
Species Reactivity	H
Tested Application(s)	E, WB
Brief Description	Pepmic offers CCR8 Antibody product,CCR8 is one of the chemokine receptors that are required as coreceptors for HIV infection.
Specific Description	CCR8 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human and murine CCR8 were cloned and designated TER1, CKR-L1, and ChemR1. The encoded seven transmembrane protein was identified as the receptor for human CC chemokine I-309 and renamed CCR8. Recently, CCR8 was found to serve as a coreceptor for diverse T-cell tropic, dual-tropic and macrophage-tropic HIV-1 strains. CCR8 mediates CC chemokine I-309 induced monocyte chemoattraction and HIV-1 envelope fusion and virus infection, which can be prevented by the CCR8 ligand I-309. CCR8 is expressed in spleen, thymus and T lymphoblastic cell lines.
Storage	CCR8 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

CX3CR1 Antibody

Product	CX3CR1 Antibody
Cat#	100-6-07A
Unit/Weight	100 μg
Unit Price	$311.00
Species Reactivity	H
Tested Application(s)	E, WB, IHC
Brief Description	Pepmic offers CX3CR1 Antibody product,CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection.
Specific Description	CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively, (1-4). The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 (5). Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine (6). CX3CR1 mediates leukocyte migration and adhesion (5). CX3CR1 is expressed in a variety of human tissues and cell lines (2).
Storage	CX3CR1 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

GLP-1 (8G9) Antibody

Product	GLP-1 (8G9) Antibody
Cat#	100-27-07A
Unit/Weight	50 μg
Unit Price	$654.00
Species Reactivity	H, M, R, Ml
Tested Application(s)	E
Brief Description	Mouse Monoclonal Antibody, Biotin-conjugated Antibody
Specific Description	Glucagon-like peptide 1 (7-36)amide (GLP-1 (7-36)amide) is the principal active form of GLP-1, the other being GLP-1 (7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far. This antibody is specific for the amidated C terminus of the peptide and does not react with GLP-1 (7-37).
Storage	Store at 4°C. Product is guaranteed 6 months from the date of shipment.

GLP-1 (11E2) Antibody

Product	GLP-1 (11E2) Antibody
Cat#	100-27-09A
Unit/Weight	50 μg
Unit Price	$654.00
Species Reactivity	H, M, R, Ml
Tested Application(s)	E, WB
Brief Description	Mouse Monoclonal Antibody, Biotin-conjugated Antibody
Specific Description	Glucagon-like peptide 1 (7-36)amide (GLP-1 (7-36)amide) is the principal active form of GLP-1, the other being GLP-1 (7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far. This antibody reacts with all forms of GLP-1, including precursor.
Storage	Store at 4°C. Product is guaranteed 6 months from the date of shipment.

Exendin-4 (35) Antibody

Product	Exendin-4 (35) Antibody
Cat#	100-27-10A
Unit/Weight	50 μg
Unit Price	$654.00
Species Reactivity	H
Tested Application(s)	E
Brief Description	Biotin-conjugated Antibody, Mouse Monoclonal Antibody
Specific Description	Exendin-4 is a 39-amino-acid peptide found in venom from the Gila monster Heloderma suspectum. It is a member of the glucagon-secretin family of peptide hormones and neuropeptides. Exendin-4 is a potent agonist of the GLP-1 receptor and hence a potent stimulator of insulin secretion. This antibody is specific for exendin-4 with no cross-reactivity with GLP-1, GLP-2 (human) or glucagon coated on ELISA wells. This antibody can be used in a sandwich ELISA to detect exendin-4.
Storage	Store at 4°C. Product is guaranteed 6 months from the date of shipment.