| Product | Spred2 Antibody |
| Cat# | 100-21-142A |
| Unit/Weight | 100 μg |
| Unit Price | $266.00 |
| Species Reactivity | H |
| Tested Application(s) | E, WB |
| Brief Description | Sprouty-related EVH1 domain-containing protein 2 |
| Specific Description | Spred2 is a member of the Sprouty family, a group of proteins that act as negative regulators during development. Like Spred1, Spred2 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. At least two isoforms of Spred2 are known to exist. This Spred2 antibody is predicted to have no cross-reactivity to Spred1 or Spred3. |
| Storage | Spred2 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
2019年5月30日星期四
Spred2 Antibody
Spred3 Antibody
| Product | Spred3 Antibody |
| Cat# | 100-21-143A |
| Unit/Weight | 100 μg |
| Unit Price | $311.00 |
| Species Reactivity | H |
| Tested Application(s) | E, WB, IHC |
| Brief Description | (IN1) Sprouty-related EVH1 domain-containing protein 3 |
| Specific Description | Spred3 is a member of the Sprouty family, a group of proteins that act as negative regulators during development. Like Spred1 and Spred2, Spred3 contains and EVH1 domain in its amino terminus and a Sprouty-related cysteine-rich (SPR) domain in its C-terminus, but does not possess a functional c-kit binding domain (KBD). The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Although Spred3 was initially reported to be expressed in brain, at least one report also indicates that Spred3 can be found in liver. At least two isoforms of Spred3 are known to exist. This Spred3 antibody is predicted to have no cross-reactivity to Spred1 or Spred2. |
| Storage | Spred3 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
STAT1 alpha Antibody
| Product | STAT1 alpha Antibody |
| Cat# | 100-21-144A |
| Unit/Weight | 100 μg |
| Unit Price | $311.00 |
| Species Reactivity | H, M, R |
| Tested Application(s) | E, WB, ICC, IP |
| Brief Description | (CT) JAK activated transcription |
| Specific Description | STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5alpha, and Stat5beta have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-alpha, IFN-beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). STAT1 has two forms, the 91 kDa STAT1alpha and the 84 kDa STAT1beta which are encoded by the same gene with splicing variant. |
| Storage | STAT1 alpha antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Stk39 Antibody
| Product | Stk39 Antibody |
| Cat# | 100-21-145A |
| Unit/Weight | 100 μg |
| Unit Price | $311.00 |
| Species Reactivity | H, M |
| Tested Application(s) | E, WB, IHC |
| Brief Description | (CT) Serine Threonine Kinase 39 |
| Specific Description | The serine/threonine kinase Stk39 belongs to the STE20 family, a group of kinases that are known to interact with inflammation-related kinases (such as p38, JNK, NKCC1, PKC-theta, WNK and MLCK), and with transcription factor AP-1. The STE 20 family is involved in diverse biological phenomena, including cell differentiation, cell transformation/ proliferation, cytoskeleton rearrangement, and the regulation of ion transporters. STK39 contains an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain and is abundantly expressed in the brain. STK39 is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled co-transporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Recent studies show that STK39 tend to be a novel candidate gene for autism and hypertension. |
| Storage | Stk39 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Stk39 Antibody
| Product | Stk39 Antibody |
| Cat# | 100-21-146A |
| Unit/Weight | 100 μg |
| Unit Price | $311.00 |
| Species Reactivity | H, M, R |
| Tested Application(s) | E, WB, IHC |
| Brief Description | (IN) Serine Threonine Kinase 39 |
| Specific Description | The serine/threonine kinase Stk39 belongs to the STE20 family, a group of kinases that are known to interact with inflammation-related kinases (such as p38, JNK, NKCC1, PKC-theta, WNK and MLCK), and with transcription factor AP-1. The STE 20 family is involved in diverse biological phenomena, including cell differentiation, cell transformation/ proliferation, cytoskeleton rearrangement, and the regulation of ion transporters. STK39 contains an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain and is abundantly expressed in the brain. STK39 is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled co-transporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Recent studies show that STK39 tend to be a novel candidate gene for autism and hypertension. |
| Storage | Stk39 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Sumo Antibody
| Product | Sumo Antibody |
| Cat# | 100-21-147A |
| Unit/Weight | 100 μg |
| Unit Price | $311.00 |
| Species Reactivity | H, M, R |
| Tested Application(s) | E, WB, IHC |
| Brief Description | small ubiquitin-like modifier 1 |
| Specific Description | The sumo family of proteins is related both structurally and functionally to ubiquitin in that they are post-translationally attached to the e-amino group of a lysine residue of the substrate protein. This sumoylation plays a number of roles in DNA replication and repair, protein targeting to various subnuclear structures, and the regulation of numerous cellular processes including the inflammatory response in mammalian cells. Sumo was initially identified as a covalent modification of RanGAP1 in studies on nuclear import in mammalian cells. More recently, sumo has been shown to be involved in the regulation of transcription factors, possibly by enhancing their interactions with co-repressors. Sumo is also thought to play some role in the modulation of ubiquitin-mediated degradation of proteins by acting as an inhibitor. At least four different isoforms of sumo are known to exist; Sumo antibody will only recognize isoform 1. |
| Storage | Sumo antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
2019年5月29日星期三
Efficient building-blocks for solid state peptide synthesis of spin-labeled peptides for EPR and DNP applications.
Efficient building-blocks for solid state peptide synthesis of spin-labeled peptides for EPR and DNP applications.
M Brodrecht, K Herr, S Bothe… - … : a European journal …, 2019 - ncbi.nlm.nih.gov
Specific spin labeling allows the site selective investigation of biomolecules by EPR and
DNP enhanced NMR spectroscopy. A novel spin labeling strategy for commercially
available Fmoc-amino acids is developed. In this approach, the PROXYL spin label is …
For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.
Quick Links:
Contact Information:
Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com
M Brodrecht, K Herr, S Bothe… - … : a European journal …, 2019 - ncbi.nlm.nih.gov
Specific spin labeling allows the site selective investigation of biomolecules by EPR and
DNP enhanced NMR spectroscopy. A novel spin labeling strategy for commercially
available Fmoc-amino acids is developed. In this approach, the PROXYL spin label is …
DNP enhanced NMR spectroscopy. A novel spin labeling strategy for commercially
available Fmoc-amino acids is developed. In this approach, the PROXYL spin label is …
Quick Links:
Contact Information:
Eva He
eva@pepmic.com
Pepmic Co., Ltdeva@pepmic.com
www.pepmic.com
[HTML] Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting
[HTML] Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting
The vaccine elicitation of broadly neutralizing responses is a central goal of HIV research.
Recently, we elicited cross-clade neutralizing responses against the N terminus of the fusion
peptide (FP), a critical component of the HIV-entry machinery. While the consistency of the …
Recently, we elicited cross-clade neutralizing responses against the N terminus of the fusion
peptide (FP), a critical component of the HIV-entry machinery. While the consistency of the …
For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.
Quick Links:
Contact Information:
Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com
Quick Links:
Contact Information:
Eva He
eva@pepmic.com
Pepmic Co., Ltdeva@pepmic.com
www.pepmic.com
Visualization of varying MT1-MMP expression with a phage display derived bicyclic peptide using µPET imaging
Visualization of varying MT1-MMP expression with a phage display derived bicyclic peptide using µPET imaging
AC Baranski, S Pavan, M Boll… - …, 2019 - thieme-connect.com
Tumor-associated membrane type 1 matrix metalloproteinase (MT1-MMP) is reported to play
an important role in extracellular matrix remodeling, resulting in metastatic dissemination,
and to be associated with poor prognosis in a variety of cancers (eg non-small cell lung …
For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.
Quick Links:
Contact Information:
Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com
AC Baranski, S Pavan, M Boll… - …, 2019 - thieme-connect.com
Tumor-associated membrane type 1 matrix metalloproteinase (MT1-MMP) is reported to play
an important role in extracellular matrix remodeling, resulting in metastatic dissemination,
and to be associated with poor prognosis in a variety of cancers (eg non-small cell lung …
an important role in extracellular matrix remodeling, resulting in metastatic dissemination,
and to be associated with poor prognosis in a variety of cancers (eg non-small cell lung …
Quick Links:
Contact Information:
Eva He
eva@pepmic.com
Pepmic Co., Ltdeva@pepmic.com
www.pepmic.com
Chaperones of the class I peptide-loading complex facilitate the constitutive presentation of endogenous antigens on HLA-DP84GGPM87
Chaperones of the class I peptide-loading complex facilitate the constitutive presentation of endogenous antigens on HLA-DP84GGPM87
M Anczurowski, K Sugata, Y Matsunaga… - Journal of …, 2019 - Elsevier
Recent work has delineated key differences in the antigen processing and presentation
mechanisms underlying HLA-DP alleles encoding glycine at position 84 of the DPβ chain
(DP 84GGPM87). These DPs are unable to associate with the class II-associated Ii peptide …
mechanisms underlying HLA-DP alleles encoding glycine at position 84 of the DPβ chain
(DP 84GGPM87). These DPs are unable to associate with the class II-associated Ii peptide …
For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.
Quick Links:
Contact Information:
Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com
Quick Links:
Contact Information:
Eva He
eva@pepmic.com
Pepmic Co., Ltdeva@pepmic.com
www.pepmic.com
Synergism of Magainins is Not Coupled to the Formation of a Well-Defined Peptide Pore
Synergism of Magainins is Not Coupled to the Formation of a Well-Defined Peptide Pore
M Pachler, I Kabelka, R Leber, I Letofsky-Papst… - Biophysical …, 2019 - cell.com
We have studied the synergistic activity of PGLa and MG2a, two antimicrobial peptides
secreted by the African clawed frog, on phosphatidylethanolamine/phosphatidylglycerol
mimics of the inner membrane of Gram negative bacteria using an array of experimental and …
For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.
Quick Links:
Contact Information:
Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com
M Pachler, I Kabelka, R Leber, I Letofsky-Papst… - Biophysical …, 2019 - cell.com
We have studied the synergistic activity of PGLa and MG2a, two antimicrobial peptides
secreted by the African clawed frog, on phosphatidylethanolamine/phosphatidylglycerol
mimics of the inner membrane of Gram negative bacteria using an array of experimental and …
secreted by the African clawed frog, on phosphatidylethanolamine/phosphatidylglycerol
mimics of the inner membrane of Gram negative bacteria using an array of experimental and …
Quick Links:
Contact Information:
Eva He
eva@pepmic.com
Pepmic Co., Ltdeva@pepmic.com
www.pepmic.com
2019年5月28日星期二
YRGDS
| Peptide Name | YRGDS |
| Sequence | Tyr-Arg-Gly-Asp-Ser |
| Species | |
| M.W | 596.26 |
| Solubility | Before reconstitution, please allow 25 to 45 minutes for the lyophilized peptide to return to room temperature. Briefly vortex the Eppendorf tube to concentrate all material at the bottom of the tube. Gently open the cap and reconstitute the peptide to the desired concentration by adding a sterile, aqueous solution to the tube. Invert the tube 5 times by hand to ensure a homogeneous solution. |
| Storage Condition | Store peptide in DRY form at 0-5°C. |
| Appearance | White powder |
| Contact Information | peptide@pepmic.com |
| Website | www.pepmic.com |
YP-30 / Dermcidin (20-49) (Human)
| Peptide Name | YP-30 / Dermcidin (20-49) (Human) |
| Sequence | Tyr-Asp-Pro-Glu-Ala-Ala-Ser-Ala-Pro-Gly-Ser-Gly-Asn-Pro-Cys-His-Glu-Ala-Ser-Ala-Ala-Gln-Lys-Glu-Asn-Ala-Gly-Glu-Asp-Pro |
| Species | Human |
| M.W | 2970.05 |
| Solubility | |
| Storage Condition | Store peptide in DRY form at 0-5°C. |
| Appearance | White Powder |
| Contact Information | peptide@pepmic.com |
| Website | www.pepmic.com |
YLPLRF-Amide
| Peptide Name | YLPLRF-Amide |
| Sequence | Tyr-Leu-Pro-Leu-Arg-Phe-NH2 |
| Species | |
| M.W | 806.99 |
| Solubility | Before reconstitution, please allow 25 to 45 minutes for the lyophilized peptide to return to room temperature. Briefly vortex the Eppendorf tube to concentrate all material at the bottom of the tube. Gently open the cap and reconstitute the peptide to the desired concentration by adding a sterile, aqueous solution to the tube. Invert the tube 5 times by hand to ensure a homogeneous solution. |
| Storage Condition | Store peptide in DRY form at 0-5°C. |
| Appearance | White powder |
| Contact Information | peptide@pepmic.com |
| Website | www.pepmic.com |
YIGSR Amide / Laminin Pentapeptide Amide
| Peptide Name | YIGSR Amide / Laminin Pentapeptide Amide |
| Sequence | Tyr-Ile-Gly-Ser-Arg-NH2 |
| Species | |
| M.W | 593.31 |
| Solubility | Before reconstitution, please allow 25 to 45 minutes for the lyophilized peptide to return to room temperature. Briefly vortex the Eppendorf tube to concentrate all material at the bottom of the tube. Gently open the cap and reconstitute the peptide to the desired concentration by adding a sterile, aqueous solution to the tube. Invert the tube 5 times by hand to ensure a homogeneous solution. |
| Storage Condition | Store peptide in DRY form at 0-5°C. |
| Appearance | White powder |
| Contact Information | peptide@pepmic.com |
| Website | www.pepmic.com |
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