HTML] Development of a peptide-siRNA nanocomplex targeting NF-κB for efficient cartilage delivery

HTML] Development of a peptide-siRNA nanocomplex targeting NF-κB for efficient cartilage delivery

H Yan, X Duan, H Pan, A Akk, LJ Sandell… - Scientific reports, 2019 - nature.com

Delivery of therapeutic small interfering RNAs (siRNAs) in an effective dose to articular
cartilage is very challenging as the cartilage dense extracellular matrix renders the
chondrocytes inaccessible, even to intra-articular injections. Herein, we used a self …

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