2018年3月1日星期四

Late‐Stage Peptide Diversification by Bioorthogonal Catalytic C H Arylation at 23° C in H2O

Late‐Stage Peptide Diversification by Bioorthogonal Catalytic C H Arylation at 23° C in H2O

Y Zhu, M Bauer, L Ackermann - Chemistry-A European Journal, 2015 - Wiley Online Library
Abstract The step-economical late-stage diversification of tryptophan-containing peptides
was accomplished through chemo-and site-selective palladium-catalyzed C [BOND] H
arylation under exceedingly mild reaction conditions. Thus, the C [BOND] H functionalization


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


发帖者 时间： 没有评论:

Mitochondria-targeted peptide reverses mitochondrial dysfunction and cognitive deficits in sepsis-associated encephalopathy

Mitochondria-targeted peptide reverses mitochondrial dysfunction and cognitive deficits in sepsis-associated encephalopathy

J Wu, M Zhang, S Hao, M Jia, M Ji, L Qiu, X Sun… - Molecular …, 2015 - Springer
Abstract Sepsis-associated encephalopathy (SAE) is associated with increased mortality,
morbidity, and long-term cognitive impairments. Its pathophysiology remains to be
determined and an effective pharmacologic treatment is lacking. The goal of this study was


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


发帖者 时间： 没有评论:

Butelase 1: a versatile ligase for peptide and protein macrocyclization

Butelase 1: a versatile ligase for peptide and protein macrocyclization

GKT Nguyen, A Kam, S Loo, AE Jansson… - Journal of the …, 2015 - ACS Publications
Macrocyclization is a valuable tool for drug design and protein engineering. Although
various methods have been developed to prepare macrocycles, a general and efficient
strategy is needed. Here we report a highly efficient method using butelase 1 to


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


发帖者 时间： 没有评论:

Light-emitting self-assembled peptide nucleic acids exhibit both stacking interactions and Watson–Crick base pairing

Light-emitting self-assembled peptide nucleic acids exhibit both stacking interactions and Watson–Crick base pairing

O Berger, L Adler-Abramovich, M Levy-Sakin… - Nature …, 2015 - nature.com
Abstract The two main branches of bionanotechnology involve the self-assembly of either
peptides or DNA. Peptide scaffolds offer chemical versatility, architectural flexibility and
structural complexity, but they lack the precise base pairing and molecular recognition


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


发帖者 时间： 没有评论:

BMP-2 derived peptide and dexamethasone incorporated mesoporous silica nanoparticles for enhanced osteogenic differentiation of bone mesenchymal stem cells

BMP-2 derived peptide and dexamethasone incorporated mesoporous silica nanoparticles for enhanced osteogenic differentiation of bone mesenchymal stem cells

X Zhou, W Feng, K Qiu, L Chen, W Wang… - … applied materials & …, 2015 - ACS Publications
Bone morphogenetic protein-2 (BMP-2), a growth factor that induces osteoblast
differentiation and promotes bone regeneration, has been extensively investigated in bone
tissue engineering. The peptides of bioactive domains, corresponding to residues 73–92 of


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


发帖者 时间： 没有评论:

Delivery and tracking of quantum dot peptide bioconjugates in an intact developing avian brain

Delivery and tracking of quantum dot peptide bioconjugates in an intact developing avian brain

R Agarwal, MS Domowicz, NB Schwartz… - ACS chemical …, 2015 - ACS Publications
Luminescent semiconductor∼ 9.5 nm nanoparticles (quantum dots: QDs) have intrinsic
physiochemical and optical properties which enable us to begin to understand the
mechanisms of nanoparticle mediated chemical/drug delivery. Here, we demonstrate the


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


发帖者 时间： 没有评论:

2018年2月28日星期三

Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens

Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens

B Bufe, T Schumann, R Kappl, I Bogeski… - Journal of Biological …, 2015 - ASBMB
Results: We report the identification of bacterial signal peptides as potent activators of
mammalian FPRs and innate immune responses and define critical features underlying FPR
peptide recognition. Conclusion: These findings identify a molecular signature for FPR


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
www.pepmic.com


发帖者 时间： 没有评论:
订阅： 博文 (Atom)