Cardiac DPP-4 inhibition by saxagliptin ameliorates isoproterenol-induced myocardial remodeling and cardiac diastolic dysfunction in rats

Cardiac DPP-4 inhibition by saxagliptin ameliorates isoproterenol-induced myocardial remodeling and cardiac diastolic dysfunction in rats

J Ikeda, N Kimoto, T Kitayama, S Kunori - Journal of Pharmacological …, 2016 - Elsevier

... The plasma samples were separated via centrifugation (1800 ×g for 20 min at 4 °C). The rats'
plasma DPP-4 activity levels were measured using a fluorometric assay with Gly-Pro-7-AMIDO-
4-METHYLCOUMARIN (Gly-Pro-AMC) (PEPTIDE INSTITUTE, Osaka, Japan) substrate. ...

Eva He

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