Peptide Synthesis: 六月 2017

2017年6月30日星期五

Investigating the physiological role of hypothalamic glucokinase in appetite and glucose homeostasis

SS Hussain - 2013 - spiral.imperial.ac.uk

... ADP Adenosine diphosphate AgRP Agouti related peptide Amp Ampicillin resistance gene AMPK
Adenosine Monophosphate Activated Protein Kinase ... GI Glucose-inhibited GIP Glucose-dependant
insulinotropic peptide GIPr Glucose-dependant insulinotropic peptide receptor ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Antimicrobial compounds

W Stensen, BE Haug, O Rekdal… - US Patent 8,598,114, 2013 - Google Patents

... Some peptidomimetic backbones will be readily available from their peptide precursors,
such as peptides which have been permethylated, suitable methods are described by Ostresh,
JM et al. in Proc. Natl. Acad. Sci. USA (1994) 91, 11138-11142. ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Polyphenols can inhibit furin in vitro as a result of the reactivity of their auto-oxidation products to proteins

J Zhu, WJM Van de Ven, T Verbiest… - Current medicinal …, 2013 - ingentaconnect.com

... Casein was obtained from Merck. The furin inhibi- tor nona-D-arginine (D9R) was obtained
from Pepscan systems. As fluorogenic peptide substrate, Pyr-RTKR-AMC (Pyr = pyroglu-
tamic acid; AMC = 7-amino-4-methyl coumarin) was used (Bachem). ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Determination of in planta gene expression by qRT-PCR

H Xu, A Weiberg, P Karlovsky - … gene expression in planta by qRT- … - ediss.uni-goettingen.de

... extra selected candidate genes VlNEP1 (encoding necrosis and ethylene inducing peptides)
whose hetero ... and normalised using two reference genes, β-tubulin and ribosomal peptide S17 ...
References 1. Bachem, CW, van der Hoeven, RS, Bruijn, SM, Vreugdenhil, D., Zabeau, M ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

An anti-steroidogenic inhibitory primer pheromone in male sea lamprey (Petromyzon marinus)

YW Chung-Davidson, H Wang, MB Bryan, H Wu… - General and …, 2013 - Elsevier

... 96%) and mammalian GnRH (HPLC purity > 96%) were purchased from BAChem Americas,
Inc ... Male sea lamprey showed phasic pattern in plasma lGnRH peptide concentrations although ...
males contained higher plasma concentrations of all three lGnRH peptides than isolated ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Iron metabolism, hepcidin, and anemia in orthotopic heart transplantation recipients treated with mammalian target of rapamycin

P Przybylowski, JS Malyszko, IC Macdougall… - Transplantation …, 2013 - Elsevier

... glucose, creatinine, NT-proBNP (N-terminal pro brain natriuretic peptide) were studied using
standard laboratory methods in the central laboratory of the hospital. Hepcidin was estimated
with an enzyme immunoassay using kits commercially available from Bachem (St Helens ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

MTI-101 (cyclized HYD1) binds a CD44 containing complex and induces necrotic cell death in multiple myeloma

AW Gebhard, P Jain, RR Nair, MF Emmons… - Molecular cancer …, 2013 - AACR

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Age and nutritional state influence the effects of cholecystokinin on energy balance

M Balaskó, I Rostás, N Füredi, A Mikó, J Tenk… - Experimental …, 2013 - Elsevier

... The latter effect indicates that CCK as a peptide hormone of the brain–gut axis can ... state can
influence the effects of CCK, since the efficacy of other peptides have been shown ...
Cholecystokinin-8 (Bachem) or solvent pyrogen-free saline (PFS) was administered either by ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Selective and potent agonists and antagonists for investigating the role of mouse oxytocin receptors

M Busnelli, E Bulgheroni, M Manning, G Kleinau… - … of Pharmacology and …, 2013 - ASPET

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Compounds for treating amyloidoses

M Mandler, R Santic, H Weninger, E Kopinits - US Patent 8,409,581, 2013 - Google Patents

... recognized the epitopes p1323 as well as p4377 and full length Aβ protein (recombinant protein;
obtained from Bachem AG, Bubendorf ... From DNA sequences, peptide sequences were deduced ...
These peptides were synthesized and characterised in binding and inhibition ELISA ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Deregulation of Fragile X-related protein 1 by the lipodystrophic lamin A p. R482W mutation elicits a myogenic gene expression program in preadipocytes

AR Oldenburg, E Delbarre, B Thiede… - Human molecular …, 2013 - academic.oup.com

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Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Spatially-defined macrocyclic compounds useful for drug discovery

É Marsault, K Benakli, HR Hoveyda… - US Patent …, 2013 - Google Patents

... molecules. Hence, peptides are primarily used as the starting point or template for the
development of new pharmaceutical leads that often results in structures that only
partially resemble, if at all, the initial active peptide. In particular ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Champacyclin, a new cyclic octapeptide from Streptomyces strain C42 isolated from the Baltic Sea

A Pesic, HI Baumann, K Kleinschmidt, P Ensle, J Wiese… - Marine drugs, 2013 - mdpi.com

... Keywords: Streptomyces champavatii; antimicrobial activity; fire blight; cyclic peptides;
sequence ladder analysis; chiral GC-PCI/EI-MS; ESI-Ion-Trap-MS n ; solid phase peptide
synthesis (SPPS); on-resin cyclization; 2D NMR. 1. Introduction. ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Neuropeptide Y is produced by adipose tissue macrophages and regulates obesity-induced inflammation

K Singer, DL Morris, KE Oatmen, T Wang… - PloS one, 2013 - journals.plos.org

... Mice were injected IP with NPY scrambled peptide (Tocris 3903, 60 µg/kg/day) or NPY
recombinant peptide (Tocris 1153, 60 µg/kg) daily for 5 ... as previously described [4]. NPY ELISA
studies were performed on media with the use of NPY high sensitivity kit from Bachem (S-1145 ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion

K Daly, M Al-Rammahi, A Moran… - American Journal of …, 2013 - Am Physiological Soc

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Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid

RM Dunham, M Thapa, VM Velazquez… - The Journal of …, 2013 - Am Assoc Immnol

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Therapeutic approaches for treating alzheimer disease and related disorders through a modulation of cell stress response

D Cohen, I Chumakov, S Nabirochkin… - US Patent …, 2013 - Google Patents

... The human amyloid peptide (Aβ 1-42 2.5 μM) produces a significant intoxication, above 40%,
compared to vehicle-treated neurons. ... The human amyloid peptide (Aβ 1-42 2.5 μM) produces
a significant intoxication, above 40%, compared to vehicle-treated neurons. ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

The voltage-dependent anion channel (VDAC) binds tissue-type plasminogen activator and promotes activation of plasminogen on the cell surface

M Gonzalez-Gronow, R Ray, F Wang… - Journal of Biological …, 2013 - ASBMB

... amyloid β peptide analogues Aβ 1–42, Aβ 1–28, Aβ 25–35, Aβ 29–40, and Aβ 31–42 were
purchased from Bachem Americas, Inc. (Torrance, CA). The VDAC 10 GKSARDVFTKGYGF
GLIKLDL 30 (Gly 10 –Leu 30 ) and t-PA 509 CQGDSGGPLVC 519 peptides were obtained ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

CD141+ dendritic cells produce prominent amounts of IFN-α after dsRNA recognition and can be targeted via DEC-205 in humanized mice

S Meixlsperger, CS Leung, PC Rämer, M Pack… - Blood, 2013 - Am Soc Hematology

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Mass spectrometry analysis shows similar release and phosphorylation profiles after PAR-1 or PAR-4 stimulation of platelets

TC van Holten, OB Bleijerveld, P Wijten… - On platelet biology … - dspace.library.uu.nl

... a kind gift from Astra Zeneca, PAR-1 activating peptide SFLLRN was obtained from Bachem
(H-2936 ... stimulated with 625 μM PAR-1 peptide and 4 mM PAR-4 peptide for 5 ... Peptides were
desalted using Sep-Pak C18 cartridges and subsequently labeled on-column with stable ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

An updated view of the intracellular mechanisms regulating cross-presentation

P Nair-Gupta, JM Blander - Frontiers in immunology, 2013 - ncbi.nlm.nih.gov

... Peptide loading on MHC I. Processed and trimmed peptides are now faced with the possibility
of being loaded on MHC I molecules that are present within endosomes and phagosomes (Figure
(Figure1C).1C). A question that remains is where these MHC I molecules are ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

Mapping of alpha-neo-endorphin-and neurokinin B-immunoreactivity in the human brainstem

E Duque, A Mangas, P Salinas, Z Díaz-Cabiale… - Brain Structure and …, 2013 - Springer

... However to date, the distribution of many neuro- peptides in the central nervous system of other ...
in rabbits against immunogens prepared by coupling the synthetic alpha-neo- endorphin peptide
(H-Tyr-Gly–Gly-Phe-Leu-Arg-Lys-Tyr- Pro-Lys-OH) (Bachem, Switzerland) to a ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

The influence of sGnRH-A and antidopaminergic drug–pimozide–on prolactin mRNA synthesis in female Prussian carp (Carassius gibelio Bloch) in vivo

J Chyb, M Socha, P Szczerbik… - Czech Journal of …, 2013 - 81.0.228.28

... substances were used: sGnRH-A – (D-Arg6, Trp7, Leu8, Pro9Net)- LHRH – an analogue of salmon
GnRH (Bachem AG, Bubendorf ... Fujimoto M., Sakamoto T., Kanetoh T., Osaka M., Moriyama S.
(2006): Prolactin-releasing peptide is essential to main ... Peptides, 27, 1104–1109. ...

Peptide synthesis, peptide modification and peptide library synthesis, please contact:

Eva He

eva@pepmic.com

Pepmic Co., Ltd

www.pepmic.com

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