2017年6月30日星期五

Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro

Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro

I Bolea, A Gella, L Monjas, C Pérez… - Current Alzheimer …, 2013 - ingentaconnect.com
... A1-40 and A1-42 (Bachem AG, Switzerland) were pre- treated with 1,1,1,3,3,3 ... Fibrillar A 1-42
(fA 1-42) was prepared by aggregating A 1-42 peptide at 37ºC as ... Briefly, experiments were
performed by incubating the peptides (40 iM) with and without ASS234 (10 iM) and ThT (35 ...



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  1. Cyclic peptide compounds are a class of cyclic compounds with special structure, widely biological activity and unique mechanism of action, which play an important role in natural products. Cyclic Peptides

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