Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects

Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects

JU Tilan, C Lu, S Galli, E Izycka-Swieszewska… - Oncotarget, 2013 - ncbi.nlm.nih.gov

... Here, we demonstrate that these growth-inhibitory actions of NPY are counteracted by hypoxia,
which converts the peptide to a growth-promoting factor. ... This truncated peptide no longer
binds to Y1R and, therefore, does not stimulate ES cell death. ...

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