MD-2 Monoclonal Antibody

Product	MD-2 Monoclonal Antibody
Cat#	100-15-17A
Unit/Weight	100 μg
Unit Price	$311.00
Species Reactivity	H, M
Tested Application(s)	E, WB, IHC
Brief Description	MD-2 (9F1B1) group of proteins that include Toll-like receptors (TLRs) and signaling molecules that recognize different pathogen-associated molecular patterns
Specific Description	MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
Storage	MD-2 monoclonal antibody can be stored at 4°C, stable for one year.