Synthesis and antiproliferative activities of doxorubicin thiol conjugates and doxorubicin-SS-cyclic peptide

Synthesis and antiproliferative activities of doxorubicin thiol conjugates and doxorubicin-SS-cyclic peptide

S Darwish, N Sadeghiani, S Fong, S Mozaffari… - European journal of …, 2019 - Elsevier

Myocardial toxicity and drug resistance caused by drug efflux are major limitations of
doxorubicin (Dox)-based chemotherapy. Dox structure modification could be used to
develop conjugates with an improved biological profile, such as antiproliferative activity and …

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