HTML] Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats

HTML] Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats

S Klein, F Frohn, F Magdaleno, C Reker-Smit… - Scientific reports, 2019 - nature.com

Rho-kinase (ROCK) activation in hepatic stellate cells (HSC) is a key mechanism promoting
liver fibrosis and portal hypertension (PTH). Specific delivery of ROCK-inhibitor Y-27632
(Y27) to HSC targeting mannose-6-phosphate-receptors reduces portal pressure and …

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