2017年6月29日星期四

Copper prevents amyloid-β1–42 from forming amyloid fibrils under near-physiological conditions in vitro

Copper prevents amyloid-β1–42 from forming amyloid fibrils under near-physiological conditions in vitro

M Mold, L Ouro-Gnao, BM Wieckowski, C Exley - Scientific reports, 2013 - ncbi.nlm.nih.gov
... this property of Cu(II) has also been demonstrated for other amyloidogenic peptides 10 ,11 ... Amyloid
β-protein (1–42) was bought from Bachem and used directly to prepare 200 μM ... The peptide is
fully dissolved under these highly alkaline conditions and exists only as monomers ...



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