Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

N Iwata, M Sekiguchi, Y Hattori, A Takahashi… - Scientific …, 2013 - ncbi.nlm.nih.gov

... brain remains unclear, but neprilysin-generated proteolytic fragments of substrate peptides may
be ... fraction, 0.1 mM succinyl-Ala-Ala-Phe-AMC (I-1315; Bachem, Bubendorf, Switzerland ... 5006;
Sigma, St Louis, MO) and 0.2 mM phosphoramidon (4082; Peptide Institute), followed ...

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