Inhibition of thrombin‐mediated factor V activation contributes to the anticoagulant activity of fibrinogen γ′

Inhibition of thrombin‐mediated factor V activation contributes to the anticoagulant activity of fibrinogen γ′

F Omarova, S Uitte De Willige… - … of Thrombosis and …, 2013 - Wiley Online Library

... low-affinity fluorogenic substrate Z-Gly-Gly-Arg-AMC (I-1140; BACHEM, Bubendorf, Switzerland ...
any TF concentration, the observed anticoagulant effects of the fibrinogen γ′ peptide are
sequence ... not attributable to aspecific charge or pH effects of these highly anionic peptides. ...

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