Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin

Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin

H Gagnon, S Beauchemin, A Kwiatkowska… - Journal of medicinal …, 2013 - ACS Publications

... which results in increased symptom severity and lethality. Previously, we developed
a nanomolar peptide inhibitor of PCs to prevent PC activation of infectious agents.
Herein, we describe a peptidomimetic approach that increases ...

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