Pregnancy-specific glycoproteins bind integrin αIIbβ3 and inhibit the platelet—fibrinogen interaction

Pregnancy-specific glycoproteins bind integrin αIIbβ3 and inhibit the platelet—fibrinogen interaction

DK Shanley, PA Kiely, K Golla, S Allen, K Martin… - PloS one, 2013 - journals.plos.org

... RGD tri-peptide motifs in the majority of human PSGs suggest that they may function like
snake venom disintegrins, which bind integrins and inhibit interactions with ligands. We
noted that human PSG1 has a KGD, rather than an RGD motif. ...

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