Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and beta cell dysfunction

Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and beta cell dysfunction

CY Westwell-Roper, JA Ehses, CB Verchere - Diabetes, 2013 - Am Diabetes Assoc

... cells to promote the synthesis of pro-inflammatory cytokines, in particular IL-1β (4,5). Other
amyloidogenic peptides also trigger an innate immune response by activating cell- ... Peptide
preparation. Human and rodent IAPP (Bachem, Torrance, CA) were dissolved ...

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