Sensitive and continuous screening of inhibitors of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) at single SPR chips

Sensitive and continuous screening of inhibitors of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) at single SPR chips

X Yi, Y Hao, N Xia, J Wang, M Quintero, D Li… - Analytical …, 2013 - ACS Publications

... Subsequent aggregation of Aβ peptides and accumulation of Aβ aggregates lead to neuronal
cell damage and ultimately Alzheimer's disease (AD).(21, 22 ... is FRET.(24-26) In FRET, two different
fluorophores are attached to the two ends of a BACE1 peptide whose cleavage by ...

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