Thrombin has biphasic effects on the nitric oxide-cGMP pathway in endothelial cells and contributes to experimental pulmonary hypertension

Thrombin has biphasic effects on the nitric oxide-cGMP pathway in endothelial cells and contributes to experimental pulmonary hypertension

KF Nickel, V Laux, R Heumann, G von Degenfeld - PloS one, 2013 - journals.plos.org

... The findings of the present study suggest a link between the activation of coagulation factors
and the nitric oxide-cGMP pathway in pulmonary endothelial cells that could be mimicked by
a direct peptide activator of PAR-1, and might be of relevance in pulmonary arterial ...

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