2018年8月31日星期五

Differences in signal peptide processing between GP3 glycoproteins of Arteriviridae

Differences in signal peptide processing between GP3 glycoproteins of Arteriviridae

M Zhang, M Veit - Virology, 2018 - Elsevier
We reported previously that carbohydrate attachment to an overlapping glycosylation site
adjacent to the signal peptide of GP3 from equine arteritis virus (EAV) prevents cleavage.
Here we investigated whether this unusual processing scheme is a feature of GP3s of other …


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*Peptide Salt: TFA, Desalt, Acetate, HCl.
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*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
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[HTML] Calcium-sensing receptor-mediated L-tryptophan-induced secretion of cholecystokinin and glucose-dependent insulinotropic peptide in swine duodenum

[HTML] Calcium-sensing receptor-mediated L-tryptophan-induced secretion of cholecystokinin and glucose-dependent insulinotropic peptide in swine duodenum

X Zhao, Y Xian, C Wang, L Ding… - Journal of …, 2018 - synapse.koreamed.org
This study aimed to elucidate the effect of tryptophan (Trp) on gut hormone secretion as well
as the roles of the calcium-sensing receptor (CaSR) and its downstream signaling pathway
in gut hormone secretion by assessing swine duodenal perfusion in vitro. Swine duodenum …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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Pepmic Co., Ltd
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[HTML] Specificity of inhibitory KIRs enables NK cells to detect changes in an altered peptide environment

[HTML] Specificity of inhibitory KIRs enables NK cells to detect changes in an altered peptide environment

P Carrillo-Bustamante, RJ de Boer, C Keşmir - Immunogenetics, 2018 - Springer
The activity of natural killer (NK) cells is tightly regulated by inhibitory and activating
receptors. Inhibitory killer immunoglobulin-like receptors (iKIRs) survey the surface of target
cells by monitoring the expression of human leukocyte antigen (HLA) class I. The binding of …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
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Polymorphism and peptide-binding specificities of porcine major histocompatibility complex (MHC) class I molecules

Polymorphism and peptide-binding specificities of porcine major histocompatibility complex (MHC) class I molecules

S Fan, Y Wang, S Wang, X Wang, Y Wu, Z Li… - Molecular …, 2018 - Elsevier
The swine lymphocyte antigen class I (SLA I) is a highly polymorphic gene superfamily that
plays an important role in swine anti-viral immune responses. However, an understanding of
the highly variable sites and peptide-binding specificities of SLA I molecule is limited. In this …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
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Pepmic Co., Ltd
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Manipulating Aggregation Behavior of the Uncharged Peptide Carbetocin

Manipulating Aggregation Behavior of the Uncharged Peptide Carbetocin

UB Høgstedt, J Østergaard, T Weiss, H Sjögren… - Journal of …, 2018 - Elsevier
Peptides are usually administered through subcutaneous injection. For low potency drugs,
this may require high concentration formulations increasing the risk of peptide aggregation,
especially for compounds without any intrinsic chargeable groups. Carbetocin was used as …

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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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Excipients for the lyoprotection of MAPKAP kinase 2 inhibitory peptide nano-polyplexes

Excipients for the lyoprotection of MAPKAP kinase 2 inhibitory peptide nano-polyplexes

AJ Mukalel, BC Evans, KV Kilchrist, EA Dailing… - Journal of Controlled …, 2018 - Elsevier
Herein, excipients are investigated to ameliorate the deleterious effects of lyophilization on
peptide-polymer nano-polyplex (NP) morphology, cellular uptake, and bioactivity. The NPs
are a previously-described platform technology for intracellular peptide delivery and are …

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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
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… function of patients with pregnancy‐induced hypertension evaluated using velocity vector imaging echocardiography and N‐terminal pro‐brain natriuretic peptide

… function of patients with pregnancy‐induced hypertension evaluated using velocity vector imaging echocardiography and N‐terminal pro‐brain natriuretic peptide

L Yu, Q Zhou, Q Peng, Z Yang - Echocardiography, 2018 - Wiley Online Library
Purpose To investigate whether acute and transient pressure overload in patients with
pregnancy‐induced hypertension (PIH) affects left ventricular (LV) systolic function. Methods
From pregnancy to 3 months after delivery, 82 patients were analyzed: 27, 25, and 30 with …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
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Pepmic Co., Ltd
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Peptide receptor radionuclide therapy and the treatment of gastroentero-pancreatic neuroendocrine tumors: current findings and future perspectives

Peptide receptor radionuclide therapy and the treatment of gastroentero-pancreatic neuroendocrine tumors: current findings and future perspectives

N Hirmas, R Jadaan, A Al-Ibraheem - Nuclear Medicine and Molecular …, 2018 - Springer
Abstract Purpose and Methods Patients with inoperable and metastasized neuroendocrine
tumors (NETs), particularly those with grades 1 and 2, usually receive treatment with
somatostatin analogues (SSAs). Peptide receptor radionuclide therapy (PRRT) has gained …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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Design of peptide-based epitope vaccine and further binding site scrutiny led to groundswell in drug discovery against Lassa virus

Design of peptide-based epitope vaccine and further binding site scrutiny led to groundswell in drug discovery against Lassa virus

MU Hossain, TM Omar, AR Oany, KMK Kibria… - 3 Biotech, 2018 - Springer
Lassa virus (LASV) is responsible for an acute viral hemorrhagic fever known as Lassa
fever. Sequence analyses of LASV proteome identified the most immunogenic protein that
led to predict both T-cell and B-cell epitopes and further target and binding site depiction …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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[HTML] Peptide data on the disulfide bond analysis of baculovirus produced Pfs25 by LC-MSMS

[HTML] Peptide data on the disulfide bond analysis of baculovirus produced Pfs25 by LC-MSMS

SM Lee, JL Plieskatt, CR King - Data in brief, 2018 - Elsevier
This article contains the peptide data obtained while performing disulfide bond mapping of
the recombinant Plasmodium falciparum protein, Pfs25, produced from the baculovirus
expression system. Pfs25 is a malaria transmission-blocking vaccine candidate, with a …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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Peptide nucleic acid as a selective recognition element for electrochemical determination of Hg2+

Peptide nucleic acid as a selective recognition element for electrochemical determination of Hg2+

A Bala, Ł Górski - Bioelectrochemistry, 2018 - Elsevier
A novel electrochemical PNA-based biosensor for the determination of Hg 2+ is described.
The receptor layer, containing single strands of polythymine PNA (peptide nucleic acid), was
formed at the surface of gold electrode. Due to the presence of thymine bases and peptide  …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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Enhanced transdermal delivery with less irritation by magainin pore-forming peptide with a N-lauroylsarcosine and sorbitan monolaurate mixture

Enhanced transdermal delivery with less irritation by magainin pore-forming peptide with a N-lauroylsarcosine and sorbitan monolaurate mixture

H Lee, J Park, YC Kim - Drug delivery and translational research, 2018 - Springer
Transdermal drug delivery is advantageous over other conventional drug administration
routes. However, it can be inefficient because of the natural barrier of the stratum corneum
which is the uppermost layer of the skin. A previous study verified that the treatment of …


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
eva@pepmic.com
Pepmic Co., Ltd
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