Radionuclide Therapy of HER2-Expressing Human Xenografts Using Affibody-Based Peptide Nucleic Acid-Mediated Pretargeting: In Vivo Proof of Principle

Radionuclide Therapy of HER2-Expressing Human Xenografts Using Affibody-Based Peptide Nucleic Acid-Mediated Pretargeting: In Vivo Proof of Principle

K Westerlund, M Altai, B Mitran… - Journal of Nuclear …, 2018 - diva-portal.org

Methods: A HER2-targeting Affibody molecule ligated with an AGTCGTGATGTAGTC PNA
hybridization probe (Z (HER2: 342)-SR-HP1) was used as the primary pretargeting agent. A
complementary AGTCGTGATGTAGTC PNA conjugated to the chelator DOTA and labeled …

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